4-Chloro-2-fluoro-5-sulfamylbenzoicacid

4-15-(Aminosulfonyl)-4-chloro-2-fluorophenyl]-N-(6-fluoro-lH- indazol-5-yl)-2-methyl-6-oxo-1, 4, 5, 6-tetrahydro-3-pyridinecarboxamide;. Step 1;. Methyl 5- (aminosulfonyl)-4-chloro-2-fluorobenzoate;. 5- (Aminosulfonyl)-4-chloro-2-fluorobenzoic acid (507 mg, 2.0 mmol) in CH30H (3 mL) with 3 drops of concentrated sulfuric acid was heated at 80 °C for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2S04). The solvent was evaporated to afford the product (508 mg, 95percent) as a white solid. MS (ES+) m/z 268 [M+H] +.

Used as the intermediate of drug azotimi

Molecular Weight:253.64
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:252.9611847
Monoisotopic Mass:252.9611847
Topological Polar Surface Area:106
Heavy Atom Count:15
Complexity:355
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes