2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLICACID

A solution of ethanolic NaOH (5 N, 15 mL) was added to a solution of compound 4 (1 mmol) in ethanol(20 mL) and the reaction mixture was stirred at room temperature for 14 h; the reaction progress was monitored by TLC. The reaction mixture was cooled and neutralized with conc. HCl. The organic layer was extracted with EtOAc and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure to obtain crude product. The crude product was purified by column chromatography using silica gel(60–120 mesh) eluting with ethyl acetate and petroleum ether to obtain 2-bromo-4-methylthiazole-5-carboxylic acid 5 as off-white solid in 76percent yield. 1HNMR spectrum (CDCl3), δ, ppm: 13.19 s (1H), 2.54 s(3H). Mass spectrum (ESI-MS): m/z 223 [M + H]+.Step 4:

Molecular Weight:222.06
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:220.91461
Monoisotopic Mass:220.91461
Topological Polar Surface Area:78.4
Heavy Atom Count:10
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes