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Azatepa

Azatepa structure

CAS No:
125-45-1
Formula:
C8H14N5OPS
Chemical Name:
Azatepa
Synonyms:
Azetepa;Azatepa;NSC-64826;diethyleniminophosphoryl-ethyl-(1,3,4-thiadiazol-2-yl)amine;N-[bis(aziridin-1-yl)phosphoryl]-N-ethyl-1,3,4-thiadiazol-2-amine;Bis(1-aziridinyl)[ethyl(1,3,4-thiadiazol-2-yl)amino]phosphineoxide

Description

Azatepa is a phosphoramide.|Azetepa is an azirine-based thiotepa derivative with alkylating activity. Azetepa is able to alkylate and crosslink DNA, causing DNA damages and eventually an inhibition of cellular proliferation.

Azatepa Basic Attributes

Molecular Weight：

259.273

Exact Mass：

259.06600

UNII：

D57I4Z650L

NSC Number：

64826

DSSTox ID：

DTXSID10154543

NCI Thesaurus Code：

C77589

HScode：

2934999090

Characteristics

PSA：

80.4

XLogP3：

0.97950

Density：

1.5g/cm3

Boiling Point：

379.7ºC at 760mmHg

Flash Point：

183.4ºC

Refractive Index：

1.645

Vapor Pressure：

5.77E-06mmHg at 25°C

Drug Information

MeSH Entry Terms：

azetepa

Azatepa Use and Manufacturing

Antineoplastic.

Computed Properties

Molecular Weight:259.27
XLogP3:0.5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:259.06566826
Monoisotopic Mass:259.06566826
Topological Polar Surface Area:80.4
Heavy Atom Count:16
Complexity:306
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Azatepa

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties

Azatepa

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