3-Bromo-1-chloro-5,5-dimethylhydantoin

241.47

241.47

204-766-9

740897W0QL

DTXSID7029162

Free-flowing white powder

40.62000

1.36870

OtherSolid

1.7598 (rough estimate)

163-164 °C

232.7±23.0 °C(Predicted)

1.6110 (estimate)

In water, 8260 mg/L at 25 deg C (est)

Keep container sealed. Cool in a cool, dry location.

6.6X10-6 mm Hg at 25 deg C (est)

Faint halogen odor

Henry's Law constant = 8.1X10-7 atm-cu m/mole at 25 °C (est)

Active bromine, 33% minimum; active chlorine, 14% minimum|Hydroxyl radical reaction rate constant = 3.1X10-12 cu cm/molecule-sec at 25 °C (est)

II

5.1

UN 3085 5.1/PG 2

3

R8;R31;R34

8-17-26-36/37/39-41-45-27

MT9195500

O,C

Stable at normal temperatures and pressures.

P210, P220, P221, P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P363, P370+P378, P391, P405, P501

H272

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

|Danger|H272 (76%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]|P210, P220, P221, P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P363, P370+P378, P391, P405, and P501|Aggregated GHS information provided by 50 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A severe eye and skin irritant.

LD50 Rat oral 600 mg/kg|LD50 Mouse oral 680 mg/kg

-Bromo-1-chloro-5,5-dimethylhydantoin's production and use as a germicide and fungicide in treatment of water as well as its use as a disinfectant, halogenating agent, catalyst and oxidant(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a structure estimation method(2), indicates that 3-bromo-1-chloro-5,5-dimethylhydantoin is expected to have very high mobility in soil(SRC). Volatilization of 3-bromo-1-chloro-5,5-dimethylhydantoin from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.1X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 3-Bromo-1-chloro-5,5-dimethylhydantoin is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.6X10-6 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2005).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a structure estimation method(2), indicates that 3-bromo-1-chloro-5,5-dimethylhydantoin is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from an estimated log Kow of -0.94(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on analogous compound 1,3-dichloro-5,5-dimethylhydantoin, 3-bromo-1-chloro-5,5-dimethylhydantoin is expected to release hypochlorous and hypobromic acid upon exposure to water(8). Biodegradation data were not available(SRC, 2005).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-bromo-1-chloro-5,5-dimethylhydantoin, which has an estimated vapor pressure of 6.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 3-bromo-1-chloro-5,5-dimethylhydantoin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.24 days(SRC), calculated from its rate constant of 3.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 3-bromo-1-chloro-5,5-dimethylhydantoin may be removed from the air by wet and dry deposition(SRC). 3-Bromo-1-chloro-5,5-dimethylhydantoin does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 3-bromo-1-chloro-5,5-dimethylhydantoin with photochemically-produced hydroxyl radicals has been estimated as 3.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5.24 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Based on analogous compound 1,3-dichloro-5,5-dimethylhydantoin, 3-bromo-1-chloro-5,5-dimethylhydantoin is expected to release hypochlorous and hypobromic acid upon exposure to water(2). 3-Bromo-1-chloro-5,5-dimethylhydantoin does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3.2 was calculated for 3-bromo-1-chloro-5,5-dimethylhydantoin(SRC), using an estimated log Kow of -0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 3-bromo-1-chloro-5,5-dimethylhydantoin can be estimated to be 23(SRC). According to a classification scheme(2), this estimated Koc value suggests that 3-bromo-1-chloro-5,5-dimethylhydantoin is expected to have very high mobility in soil.

The Henry's Law constant for 3-bromo-1-chloro-5,5-dimethylhydantoin is estimated as 8.1X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 3-bromo-1-chloro-5,5-dimethylhydantoin is expected to be essentially nonvolatile from moist soil(SRC) and water surfaces(2). 3-Bromo-1-chloro-5,5-dimethylhydantoin is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.6X10-6 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to 3-bromo-1-chloro-5,5-dimethylhydantoin may occur through inhalation of dust and dermal contact with this compound at workplaces where 3-bromo-1-chloro-5,5-dimethylhydantoin is produced or used. The greatest potential for exposure among the general population is from dermal contact with this compound which is used as a disinfectant in swimming pools. (SRC)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

Soap, cleaning compound, and toilet preparation manufacturing|2,4-Imidazolidinedione, 3-bromo-1-chloro-5,5-dimethyl-: ACTIVE