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Promazine hydrochloride

Promazine hydrochloride structure

CAS No:
53-60-1
Formula:
C17H20N2S.ClH
Chemical Name:
Promazine hydrochloride
Synonyms:
10H-Phenothiazine-10-propanamine,N,N-dimethyl-,hydrochloride (1:1);Phenothiazine,10-[3-(dimethylamino)propyl]-,monohydrochloride;10H-Phenothiazine-10-propanamine,N,N-dimethyl-,monohydrochloride;10-(γ-Dimethylamino-n-propyl)phenothiazine hydrochloride;Promazine hydrochloride;Esparinal;Sparine;Promazine monohydrochloride;Propazin (pharmaceutical);Propazine;Propazin;Promwill;Talofen;Liranol;Prolactyl;Prozine
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

Promazine Hydrochloride is the hydrochloride salt form of promazine, a phenothiazine derivative with antipsychotic and antiemetic properties. Promazine hydrochloride blocks postsynaptic dopamine receptors D1 and D2 in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks alpha-adrenergic receptors and exhibits strong anticholinergic activity.|A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Promazine hydrochloride Basic Attributes

Molecular Weight：

320.88

Exact Mass：

320.11100

EC Number：

200-179-7

UNII：

U16EOR79U4

NSC Number：

757300|17468

DSSTox ID：

DTXSID4046949

NCI Thesaurus Code：

C47691

HScode：

2934300000

Characteristics

PSA：

31.78000

XLogP3：

5.10800

Density：

1.1435 (rough estimate)

Melting Point：

181 °C (decomp)

Boiling Point：

412.7ºC at 760mmHg

Flash Point：

203.4ºC

Water Solubility：

>48.1 [ug/mL]

Storage Conditions：

2-8°C

Collision Cross Section：

161.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-43

safety instructions：

RTECS Number：

SO8575000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302-H317

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Hydrochloride, Promazine

Promazine hydrochloride Use and Manufacturing

Uses

Antipsychotic. Tranquilizer.

Manufacturing Info：

10H-Phenothiazine-10-propanamine, N,N-dimethyl-, hydrochloride (1:1): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:320.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:320.1113975
Monoisotopic Mass:320.1113975
Topological Polar Surface Area:31.8
Heavy Atom Count:21
Complexity:285
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Promazine hydrochloride

CAS No.: 53-60-1

Content: 99.00%

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