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(+)-Dicentrine

(+)-Dicentrine structure

CAS No:
517-66-8
Formula:
C20H21NO4
Chemical Name:
(+)-Dicentrine
Synonyms:
5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-,(7aS)-;6aα-Aporphine,9,10-dimethoxy-1,2-(methylenedioxy)-;Dicentrine;5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-,(S)-;(7aS)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline;Eximine;9,10-Dimethoxy-1,2-(methylenedioxy)-6aα-aporphine;1,2-(Methylenedioxy)-9,10-dimethoxy-6aα-aporphine;O,N-Dimethyllitseferine;(+)-Dicentrine;d-Dicentrine;S-(+)-Dicentrine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Dicentrine is a natural product isolated from the plant Lindera megaphylla with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates[1].

Dicentrine is an aporphine alkaloid.

(+)-Dicentrine Basic Attributes

Molecular Weight：

339.385

Exact Mass：

339.39

UNII：

J2ZGT5M0N7

NSC Number：

406035

DSSTox ID：

DTXSID10199651

Characteristics

PSA：

40.16000

XLogP3：

3.98

Density：

1.3±0.1 g/cm3

Melting Point：

168-169 °C

Boiling Point：

480.7±45.0 °C at 760 mmHg

Flash Point：

142.7±25.9 °C

Refractive Index：

1.616

Drug Information

MeSH Entry Terms：

(R)-(-)-dicentrine

Computed Properties

Molecular Weight:339.4
XLogP3:3.2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:339.14705815
Monoisotopic Mass:339.14705815
Topological Polar Surface Area:40.2
Heavy Atom Count:25
Complexity:502
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes