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Nitroglycerin

Nitroglycerin structure

CAS No:
55-63-0
Formula:
C3H5N3O9
Chemical Name:
Nitroglycerin
Synonyms:
1,2,3-Propanetriol,1,2,3-trinitrate;Nitroglycerin;1,2,3-Propanetriol,trinitrate;Anginine;Blasting oil;Glonoin;Glyceryl nitrate;Glyceryl trinitrate;GTN;NG;Niglycon;Nitrine-TDC;Nitroglycerine;Nitroglycerol;Nitroglyn;Nitrolingual;Nitrolowe;Nitro-Span;NTG;Perglottal;1,2,3-Propanetriyl nitrate;Trinitrin;Trinitroglycerin;Trinitroglycerol;Glycerol trinitrate;Propanetriol trinitrate;Angibid;Angiolingual;Angorin;Cardamist;Lenitral;Myoglycerin;Nitromel;Nitrong;Nitrorectal;Nitroretard;Nitrolan;Nitro-lent;Nitrozell retard;Nitrostat;Trinalgon;Klavikordal;Nysconitrine;Vasoglyn;Glycerin trinitrate;S.N.G.;Gilucor nitro;Nitora;Trinitrol;Nitrostabilin;Temponitrin;Nitroletten;Niglin;Nitrol;Nitrol (pharmaceutical);Nitrin;Nitrine;NK 843;Nitro-Dur;Nitroderm;Chitamite;Nitropercuten;Penobel 2;Perlinganit;Epinitril;Deponit;Nitro-Bid;Transderm-Nitro;Nitrocardin;Triniplas;Minitran;Minitran (nitroglycerin);Tridil;SDM 71;SDM 75;Nitrogard;SDM 77;Millisrol;Nitronal;Nitrolar;SDM 78;SDM 79;Nitrodisc;Transderm-Nitro TTS;Trinitrosan;Nitrolande;Aquo-Trinitrosan;Diafusor;SDM 74;Glycerol nitric acid triester;Nitroglin;Nitro Mack;Adesitrin;Nitro-PRN;Sustac;Sutonit;Niong;Nitrosigma;SDM 7;Nitrofortin;Coro-Nitro;Percutol;Corditrine;Suscard;Transiderm-Nitro;Reminitrol;Nitro-Gesani;Nitrol Ointment;Lentonitrina;Cordipatch;SDM 17;SDM 20;SDM 26;SDM 27;Discotrine;SDM 36;SDM 47;Susadrin;Gilucor;Nitroderm TTS;GTN (explosive);100292-13-5;105469-31-6;8013-23-8;9010-02-0;80066-48-4
Categories:
Organic Chemistry > Nitro Compounds

Description

Nitroglycerin is a pale yellow oily liquid and also available in the form of rhombic crystals. It is highly explosive. It is used in combination with ethylene glycol dinitrite in the manufacture of dynamites. It is slightly soluble in water and miscible with acetone, ether, benzene, and other organic solvents. Nitroglycerin is incompatible with strong acids, such as hydrochloric acid, sulphuric acid, and nitric acid, and also with ozone and causes violent reactions. Nitroglycerin is a powerful

Nitroglycerin Basic Attributes

Molecular Weight：

227.09

Exact Mass：

227.09

EC Number：

200-240-8

HScode：

2920900002

Characteristics

PSA：

165

XLogP3：

1.62

Appearance：

Glyceryl trinitrate solution appears as a colorless solution of glyceryl trinitrate (nitroglycerin) in water. If allowed to dry out, the remaining nitroglycerin is explosive.

Density：

1.6009 g/cm³ @ Temp: 15 °C

Melting Point：

13 °C

Boiling Point：

250 °C

Flash Point：

12°C

Refractive Index：

nD15 1.474

Water Solubility：

H2O: 1.25g/L(25 ºC);Miscible with acetone and with anhydrous ethanol

Storage Conditions：

-20°C

Vapor Pressure：

Vapour pressure, Pa at 20°C: 0.03

Vapor Density：

Relative vapour density (air = 1): 7.8

Toxicity：

Oral-rat LD50: 7060 mg/kg; Oral-Mouse LD50: 3450 mg/kg

Flammability characteristics：

Flammable; contains toxic nitroglycerin

Explosive limit：

Undiluted nitroglycerin should be handled cautiously since it is a powerful explosive that can be exploded by percussion or excessive heat. Nitroglycerin is diluted with lactose, dextrose, alcohol, proplyene glycol, or another inert excipient to permit safe handling.

Taste：

Sweet, burning taste

PKA：

-5.6None

Safety Information

Packing level：

Hazard category：

1.1A

Transport codes：

1993

wgk germany：

hazard class code：

11-51/53-33-26/27/28-3-36-20/21/22-23/24/25

safety instructions：

7-16-61-45-36/37-35-33-26

RTECS Number：

QX2100000

Marks：

E,T+,N,Xn,T

Storage features：

Handle lightly; storeroom ventilated, away from open flames, high temperature, sunlight; stored separately from oxidants, flammable materials, food materials

Stability/Shelf Life：

The rate of nitroglycerin hydrolysis becomes significant at low pH values and is also quite rapid in alkaline solutions. In neutral to weakly acidic solutions, the drug is stable. No loss was observed over 136 days at room temperature at pH 3 to 5.

Precautionary statement(s)：

P210-P370 + P378-P403 + P235

Hazard Statements：

H225

Toxicity

Toxicity class：

moderately toxic

Nitroglycerin Use and Manufacturing

Glyceryl trinitrate (GTN; nitroglycerin) is a representative compound from the organic nitrate ester family. Introduced in 1879, it has been used as a therapeutic agent in the treatment of angina pectoris. In the later part of the nineteenth century, the explosive property of nitroglycerin was discovered, and it then became the active component of dynamite. Glyceryl trinitrate, ethylene glycol dinitrate, and other nitrate esters are commonly used in military and mining explosives. In preparing dynamite, these nitrate esters are absorbed in a dope of oxidizing salts and various inert fillers. Nitroglycerin has medicinal use as a vasodilator. The main medical use of nitroglycerin is to treat angina pectoris. Nitroglycerin was first used to treat this condition in the late 19th century. It is prescribed today in various forms (tablet, ointment, patches, and injection) for patients who suffer from angina pectoris. Nitroglycerin is marketed under various trade names: Nitro-Dur, Nitrostat, Nitrospan, Nitro-Bid, and Tridil. When used in medications, the name glyceryl trinitrate is often used instead of nitroglycerin. Vasodilator (coronary) Minitran (3M Pharmaceuticals); Nitro-Bid (Sanofi Aventis); Nitro-Dur (Key); Nitrol (Rorer); Nitrolingual (Pohl Boskamp); Nitrostat (Pfizer); Transderm-Nitro (Novartis). Nitroglycerin is an explosive agent contained in dynamite and an antianginal and vasodilator treatment. It is a well-known irritant in dynamite manufacturers. It can also cause allergic reactions in employees of manufacturers of explosives, or in the pharmaceutical industries. Nitroglycerin can cross react with isosorbide dinitrate.

Computed Properties

Molecular Weight:227.09
XLogP3:1.6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:227.00257875
Monoisotopic Mass:227.00257875
Topological Polar Surface Area:165
Heavy Atom Count:15
Complexity:219
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not specified in the provided information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

DYNAMIT NOBEL GMBH EXPLOSIVSTOFF UND SYSTEMTECHNIK

France
Active
Weizhi Pharmaceutical Co., Ltd.

China
Active
COPPERHEAD INVESTMENTS INC

United States
Active

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