Histamine dihydrochloride
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Histamine dihydrochloride
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CAS No:
56-92-8
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Formula:
C5H9N3.2ClH
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Chemical Name:
Histamine dihydrochloride
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Synonyms:
1H-Imidazole-5-ethanamine,hydrochloride (1:2);Histamine,dihydrochloride;1H-Imidazole-4-ethanamine,dihydrochloride;Histamine dichloride;4-(2-Aminoethyl)imidazole dihydrochloride;Histamine hydrochloride;Histamine chloride;Histaminediium dichloride;Peremin;2-(1H-Imidazol-4-yl)ethylamine dihydrochloride;Ceplene;2-(1H-Imidazol-4-yl)ethanamine dihydrochloride;Histamine dihydrochloride;2-(4-Imidazolyl)ethylamine dihydrochloride;2-(1H-Imidazol-4-yl)ethan-1-amine dihydrochloride;2-(1H-Imidazol-5-yl)ethan-1-amine dihydrochloride
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CAS No:
Description
white powder
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Histamine dihydrochloride Basic Attributes
184.07
183.033005
3624116
200-298-4
F9I23AC4PQ
757057|257873
2933290090
Characteristics
54.7
2.21520
white to off-white powder
1.14 g/cm3
240-243 °C
331ºC at 760 mmHg
180.3ºC
H2O: 0.1 g/mL, clear, colorless
2-8°C
Safety Information
IRRITANT
3335
2
36/37/38-42/43-42-22
22-26-36/37/39-45-37-36/37
MS1575000
Xn,Xi
Irritant
Stable. Incompatible with strong oxidizing agents.
P261-P280-P305 + P351 + P338-P342 + P311
H315-H317-H319-H334-H335
Drug Information
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)
Ceplene
Histamine dihydrochloride Use and Manufacturing
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.
Computed Properties
Molecular Weight:147.60
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:147.0563250
Monoisotopic Mass:147.0563250
Topological Polar Surface Area:54.7
Heavy Atom Count:9
Complexity:64.7
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Stimulate the body to produce anti-histamine antibodies, thereby eliminating the pathogenic effects of endogenous histamine
Registered Holders
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Laboratorium Ofichem BV
Active
United States
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JUBILANT BIOSYS LTD
Active
United States
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LABORATORIOS ESPINOS Y BOFILL S.A. (LEBSA)
Active
Japan
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