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Ethinyl Estradiol

Ethinyl Estradiol structure

CAS No:
57-63-6
Formula:
C20H24O2
Chemical Name:
Ethinyl Estradiol
Synonyms:
ETHINYL ESTRADIOL;LYNORAL;19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17ALPHA-DIOL;19-NOR-1,3,5[10],17ALPHA-PREGNATRIEN-20-YNE-3,17-DIOL;1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL;ACETENYL ESTRADIOL;17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL;17ALPHA-ETHYNYLESTRADIOL
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.Target: Estrogen ReceptorEthinyl estradiol (EE), also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl estradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for

Ethynyl estradiol (EE) is a synthetic form of estrogen that is majorly employed in numerous hormonal contraceptives in combination with progestins. Occasionally, it is also used as a constituent of menopausal hormone therapy with combination with progestins for treating menopausal symptoms. Previously, the drug was used solely for numerous indications such as treatment of prostate cancer and gynecological disorders.Ethynyl estradiol is a semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It is normally administred orally and is marketed mostly as a combination oral contraceptive under various brand names such as Alesse, Tri-cyclen, Yasmin, and Triphasil. A black box warning is normally labelled on the packaging that states that the drug should not be used in smoking women who are over 35 years old as it can lead to increased risk of serious cardiovascular side effects.

Off-White to Light-Yellow Crystalline Powder

Ethinylestradiol is a white to creamy-white powder. Odorless.

ChEBI: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.

Ethinyl Estradiol Basic Attributes

Molecular Weight：

296.41

Exact Mass：

296.40

BRN：

2419975

EC Number：

200-342-2

TSCA：

TSCA listed

Color/Form：

White to Light yellow to Light orange

HScode：

29372390

Characteristics

PSA：

40.46000

XLogP3：

3.7

Appearance：

Ethinylestradiol is a fine white to creamy white powder. A synthetic steroid. Used in combination with progestogen as an oral contraceptive.

Density：

1.0944 (rough estimate)

Melting Point：

182-183 °C(lit.)

Boiling Point：

378°C (rough estimate)

Flash Point：

211.2ºC

Refractive Index：

-30 ° (C=0.4, Pyridine)

Water Solubility：

0.0113 mg/mL at 27 °C

Storage Conditions：

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition so

Vapor Pressure：

1.95X10-9 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in rat: 960mg/kg

Specific rotation：

Specific optical rotation: 3.5 deg at 24 °C/D (c = 2 in dioxane); -29.5 deg at 24 °C/D (c = 2 in pyridine)

Odor：

Odorless

PKA：

pKa 10.32 (Uncertain)

Henrys Law Constant：

1.2×106mol/(m3Pa) at 25℃, HSDB (2015)

Air and Water Reactions：

Air and light sensitive . Insoluble in water.

Reactivity Profile：

Ethynyl estradiol may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to generate gaseous hydrogen.

Critical Temperature & Pressure：

room temp

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

3077

wgk germany：

hazard class code：

T,F

safety instructions：

53-36/37/39-45-36/37-16

RTECS Number：

RC8925000

Marks：

Storage features：

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a refrigerator under an inert atmosphereand protect from exposure to light.

Precautionary statement(s)：

P201-P308 + P313

Hazard Statements：

45-22-39/23/24/25-23/24/25-11

Hazardous Reactivities：

May react exothermically with reducing agents to generate flammable gaseous hydrogen. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

RIDADR：

UN1230 - class 3 - PG 2 - Methanol, solution

Fire Hazards：

The flash point data for Ethynyl estradiol are not available. Ethynyl estradiol is probably combustible.

Drug Information

Health Hazards：

ACUTE/CHRONIC HAZARDS: When heated to decomposition Ethynyl estradiol emits acrid smoke and fumes.

Ethinyl Estradiol Use and Manufacturing

1. A metabolite of 17a-Ethynylestradiol
2. A synthetic steroid with high oral estrogenic potency
3. Estrogen, plus progestogen as oral contraceptive
4. A synthetic estradiol analog.

A synthetic estradiol analog.

A metabolite of 17a-Ethynylestradiol

A synthetic steroid with high oral estrogenic potency

estrogen, plus progestogen as oral contraceptive

Computed Properties

Molecular Weight:296.4
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:296.177630004
Monoisotopic Mass:296.177630004
Topological Polar Surface Area:40.5
Heavy Atom Count:22
Complexity:505
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Tetrahydrofuran

Isobutanol

Drug Function and Efficacy

It inhibits ovulation, changes cervical secretions, makes the menstrual cycle more regular, relieves dysmenorrhea, reduces bleeding, and reduces the occurrence of iron deficiency. When combined with drospirenone, it helps to increase the level of sex hormone binding globulin (SHBG), which is beneficial for binding with endogenous androgens and inactivating them. It may reduce the incidence of ovarian cysts, pelvic inflammatory disease, benign breast disease and ectopic pregnancy (further confirmation is needed).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ethinyl estradiol
Manufacturer	Qinhuangdao Zizhu Pharmaceutical Co., Ltd.

Drospirenone ethinyl estradiol tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 3 mg of drospirenone and 0.03 mg of ethinyl estradiol.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 0.03 mg of ethinyl estradiol and 3 mg of drospirenone

Norgestrel Compound Tablets
Ingredients	This product is a compound preparation, each tablet contains 0.3 mg of norgestrel and 0.03 mg of ethinyl estradiol.
Indication	1. Drugs that can reduce the contraceptive effect of this product include: antibacterial drugs, especially oral broad-spectrum antibacterial drugs; drug enzyme inducers, such as rifampicin, phenobarbital, phenytoin sodium, etc., which should be avoided at the same time. 2. This product can weaken the efficacy of antihypertensive drugs, anticoagulants and hypoglycemic drugs. 3. This product can enhance the efficacy of tricyclic antidepressants. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Norgestrel 0.3mg, ethinyl estradiol 0.03mg
Manufacturer	Nanjing Baijingyu Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

VALARY LAB PRIVATE LIMITED

India
Active
ZHEJIANG XIANJU JUNYE PHARMACEUTICAL CO., LIMITED

Hongkong, China
Active
Bayer Ag

Finland
Active

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Guide of Ethinyl Estradiol

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Ethinyl Estradiol

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