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Armepavine

Armepavine structure

CAS No:
524-20-9
Formula:
C19H23NO3
Chemical Name:
Armepavine
Synonyms:
Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-;Armepavine;Phenol,4-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]-,(R)-;4-[[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenol;Alkaloid D,from Evonymuseuropaea;Evoeuropine;(-)-Armepavine;(R)-(-)-Armepavine;NSC 110381
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades[1].

Armepavine is a member of isoquinolines.

Armepavine Basic Attributes

Molecular Weight：

313.397

Exact Mass：

313.39

UNII：

RE6Z59021R

HScode：

2933499090

Characteristics

PSA：

41.9

XLogP3：

3.11900

Density：

1.151g/cm3

Melting Point：

166 °C

Boiling Point：

460.5ºC at 760 mmHg

Flash Point：

232.3ºC

Refractive Index：

1.584

Specific rotation：

D20 -117.6° (CHCl3) (Knabe); D27 -103.2° (Farber)

Drug Information

MeSH Entry Terms：

armepavine

Computed Properties

Molecular Weight:313.4
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:313.16779360
Monoisotopic Mass:313.16779360
Topological Polar Surface Area:41.9
Heavy Atom Count:23
Complexity:370
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Armepavine

CAS No.: 524-20-9

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