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Desipramine hydrochloride

Desipramine hydrochloride structure

CAS No:
58-28-6
Formula:
C18H22N2.ClH
Chemical Name:
Desipramine hydrochloride
Synonyms:
5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N-methyl-,hydrochloride (1:1);5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]-,monohydrochloride;5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N-methyl-,monohydrochloride;EX 4355;JB 8181;G 35020;Demethylimipramine hydrochloride;Desipramine hydrochloride;10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride;DMI hydrochloride;GMI;N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride;Pertofrane;Desipramine monohydrochloride;Pertofran;Desmethylimipramine monohydrochloride;Desmethylimipramine chloride;5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride;Desimipramine-hydrochloride;Norpramin;Desmethylimipramine-hydrochloride;RMI 9384A;NSC 114901;Nortrimil;Petilil
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

Desipramine Hydrochloride is the hydrochloride salt form of desipramine, a secondary amine tricyclic antidepressant (TCA). In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.|A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.

Desipramine hydrochloride Basic Attributes

Molecular Weight：

302.84

Exact Mass：

302.154968

EC Number：

200-373-1

UNII：

1Y58DO4MY1

NSC Number：

756719|114901

DSSTox ID：

DTXSID9046942

NCI Thesaurus Code：

C28979

HScode：

2933996100

Characteristics

PSA：

15.27000

XLogP3：

4.79070

Appearance：

white to off-white powder

Melting Point：

215-216 °C

Boiling Point：

407.4ºC at 760 mmHg

Flash Point：

11 °C

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)

Collision Cross Section：

162.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

UN 1230 3/PG 2

wgk germany：

hazard class code：

22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25

safety instructions：

7-16-36/37-45-26-24-22

RTECS Number：

HO0525000

Marks：

Xn,T,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Danger|H302 (97.78%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P285, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)|Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

Apo Desipramine

Desipramine hydrochloride Use and Manufacturing

Uses

Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:302.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:302.1549764
Monoisotopic Mass:302.1549764
Topological Polar Surface Area:15.3
Heavy Atom Count:21
Complexity:267
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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CAS No.: 58-28-6

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Guide of Desipramine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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