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(±)-Tetrabenazine

(±)-Tetrabenazine structure

CAS No:
58-46-8
Formula:
C19H27NO3
Chemical Name:
(±)-Tetrabenazine
Synonyms:
2H-Benzo[a]quinolizin-2-one,1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-,(3R,11bR)-rel-;2H-Benzo[a]quinolizin-2-one,1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-;2H-Benzo[a]quinolizin-2-one,1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-,cis-;rel-(3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one;Ro 1-9569;cis-2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine;Tetrabenazine;Rubigen;NSC 169886;NSC 172187;(±)-Tetrabenazine;Xenazine;2104-79-2;39630-28-9
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.Target: Otherstetrabenazine (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. TBZ is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. In contrast to typical neuroleptics, TBZ has not been demonstrated to cause tardive dyskinesia [1, 2]. Twenty patients with tardive dyskinesia (mean duration = 43.7 months) were videotaped before and after te

(±)-Tetrabenazine Basic Attributes

Molecular Weight：

317.429

Exact Mass：

317.42

EC Number：

200-383-6

HScode：

2933990090

Characteristics

PSA：

38.8

XLogP3：

3.48

Appearance：

Solid

Density：

1.1±0.1 g/cm3

Melting Point：

128 °C

Boiling Point：

448.9±45.0 °C at 760 mmHg

Flash Point：

225.3±28.7 °C

Refractive Index：

1.554

Water Solubility：

H2O: Sparingly soluble

Storage Conditions：

2-8ºC

Vapor Pressure：

5.31X10-7 mm Hg at 25 °C (est)

PKA：

6.51None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3249

wgk germany：

hazard class code：

R22

safety instructions：

24/25

RTECS Number：

DK2275000

Marks：

Xn: Harmful;

Stability/Shelf Life：

Stable under recommended storage conditions.

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

(±)-Tetrabenazine Use and Manufacturing

Dopamine depleting agent. An antidyskinetic; antipsychotic.

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