 Home > Encyclopedia > 2-Chloroadenosine

2-Chloroadenosine

2-Chloroadenosine structure

CAS No:
146-77-0
Formula:
C10H12ClN5O4
Chemical Name:
2-Chloroadenosine
Synonyms:
Adenosine,2-chloro-;2-Chloroadenosine;2-Chloro-D-adenosine;Antibiotic AT 265B;NSC 36896;CADO
Categories:
Pharmaceutical Intermediates > Cardiovascular Agents

Description

2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].

(2R,3R,4S,5R)-2-(6-amino-2-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol is a purine nucleoside.|2-Chloroadenosine. A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.

2-Chloroadenosine Basic Attributes

Molecular Weight：

301.69

Exact Mass：

301.69

EC Number：

205-678-3

UNII：

7W7ZUG45G8

Characteristics

PSA：

140

XLogP3：

-0.1

Appearance：

white powder

Density：

2.2±0.1 g/cm3

Melting Point：

135 °C

Boiling Point：

591.8ºC at 760 mmHg

Flash Point：

342.8±34.3 °C

Refractive Index：

1.912

Water Solubility：

soluble in water.H2O: 10 mg/mL, clear, colorless

Storage Conditions：

Store at +4°C

Toxicity：

Oral-Mouse LD: > 100 mg/kg; Intravenous-Mouse LDL0: 50 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides and chloride fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

AU7357550

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, P501

Hazard Statements：

H302+H312+H332

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

2 Chloroadenosine

2-Chloroadenosine Use and Manufacturing

A selective A1-adenosine receptor agonist.Induces apoptosis

Computed Properties

Molecular Weight:301.69
XLogP3:-0.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:301.0577816
Monoisotopic Mass:301.0577816
Topological Polar Surface Area:140
Heavy Atom Count:20
Complexity:367
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Chloroadenosine

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

6-Amino-2-chloropurine riboside >=98.0% Nucleoside Purine made in china

CAS No.: 146-77-0

Inquiry
Dingwang Technology (Wuhan) Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

2-Chloroadenosine/2-Cado 98% Powder 146-77-0 Senwayer

CAS No.: 146-77-0

Grade: Top Product

Content: 98%

Inquiry
Wuhu Nuowei Chemistry Technologies Co., Ltd. Contact Supplier

CN
7 YRS

Business licensed Certified factory

Manufactory Supplier of Carbohydrates,Nucleosides & Nucleotides,Ionic liquids

2-Chloroadenosine

CAS No.: 146-77-0

Grade: Guaranteed Reagent

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity 2-Chlor oadenosine 99% see COA kanbei

CAS No.: 146-77-0

Grade: Industrial Grade

Content: 99%

Inquiry