Diphenylpyraline
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Diphenylpyraline
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CAS No:
147-20-6
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Formula:
C19H23NO
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Chemical Name:
Diphenylpyraline
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Synonyms:
Piperidine,4-(diphenylmethoxy)-1-methyl-;4-(Diphenylmethoxy)-1-methylpiperidine;AN 1041;4-(Benzhydryloxy)-1-methylpiperidine;Diphenylpyraline;Diphenylpyrilene;1-Methyl-4-piperidyl benzhydryl ether;N-Methyl-4-(benzhydryloxy)piperidine;Hystryl;Lyssipoll;Mepiben;Neargal;P 253;Diphenpyraline
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CAS No:
Description
ChEBI: A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Solid
Diphenylpyraline is a member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold. It has a role as a H1-receptor antagonist and a cholinergic antagonist. It is a member of piperidines and a tertiary amine.|Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Diphenylpyraline Basic Attributes
281.399
281.39
205-686-7
33361OE3AV
DTXSID3022952
R - Respiratory system
2933399090
Characteristics
12.5
3.7
Solid
1.0423 (rough estimate)
206
158-160 °C @ Press: 2 Torr
111.6ºC
1.5000 (estimate)
1.88e-02 g/L
6.18E-06mmHg at 25°C
Drug Information
For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa.
Well absorbed after oral administration.
Hepatic
Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.
4-diphenylmethoxy-1-methylpiperidine
Diphenylpyraline Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals