 Home > Encyclopedia > Rhapontigenin

Rhapontigenin

Rhapontigenin structure

CAS No:
500-65-2
Formula:
C15H14O4
Chemical Name:
Rhapontigenin
Synonyms:
1,3-Benzenediol,5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-;3,3′,5-Stilbenetriol,4′-methoxy-,(E)-;1,3-Benzenediol,5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]-,(E)-;5-[(1E)-2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol;Pontigenin;Prontigenin;Protigenin;Rhapontigenin;Rhapontin genin;Rhapontin aglycone;29700-24-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively[1].

Rhapontigenin is a stilbenoid.

Rhapontigenin Basic Attributes

Molecular Weight：

258.273

Exact Mass：

258.27

Characteristics

PSA：

69.9

XLogP3：

2.82

Appearance：

White, off grey crystal powder

Density：

1.3±0.1 g/cm3

Melting Point：

180-181 °C @ Solvent: Acetic acid

Boiling Point：

503.6±38.0 °C at 760 mmHg

Flash Point：

258.4±26.8 °C

Refractive Index：

1.722

Drug Information

MeSH Entry Terms：

rhapontigenin

Rhapontigenin Use and Manufacturing

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical]

Computed Properties

Molecular Weight:258.27
XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:258.08920892
Monoisotopic Mass:258.08920892
Topological Polar Surface Area:69.9
Heavy Atom Count:19
Complexity:295
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Rhapontigenin

Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

rhapontigenin

CAS No.: 500-65-2

Grade: industrial Grade

Content: 98%

Inquiry
Chongqing Chemdad Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Amino acid,intermediates

rhapontigenin

CAS No.: 500-65-2

Inquiry