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Herbacetin

Herbacetin structure

CAS No:
527-95-7
Formula:
C15H10O7
Chemical Name:
Herbacetin
Synonyms:
4H-1-Benzopyran-4-one,3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-;Flavone,3,4′,5,7,8-pentahydroxy-;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Herbacetin;3,5,7,8,4′-Pentahydroxyflavone;Isoarticulatidin;8-Hydroxykaempferol;2-(4-Hydroxyphenyl)-3,5,7,8-tetrakis(oxidanyl)chromen-4-one;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2].

Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It derives from a kaempferol.

Herbacetin Basic Attributes

Molecular Weight：

302.237

Exact Mass：

302.24

DSSTox ID：

DTXSID70415061

HScode：

2914501900

Characteristics

PSA：

127

XLogP3：

1.14

Density：

1.799

Melting Point：

266 °C

Boiling Point：

618.7±55.0 °C at 760 mmHg

Flash Point：

239.0±25.0 °C

Refractive Index：

1.823

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

Drug Information

MeSH Entry Terms：

herbacetin

Herbacetin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:302.23
XLogP3:2.2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:302.04265265
Monoisotopic Mass:302.04265265
Topological Polar Surface Area:127
Heavy Atom Count:22
Complexity:480
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not clearly described

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Yuancao brand Yuancao Xuepingkang granules
Specifications	15g/bag

SEDUM ACRE- sedum acre_liquid
Manufacturer	Washington Homeopathic Products

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Guide of Herbacetin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
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