5-Nonanone

142.24

142.24

1743583

207-946-5

V8B2Y1BZ3S

14761

1224

DTXSID7022045

Colorless to light yellow liquid

29141990

17.1

2.7

Clear colorless to slightly yellow Liquid

0.8217 g/cm³ @ Temp: 20 °C

-5.9 °C

188.4 °C

141 °F

1.417

256mg/L(25 ºC)

Store below +30°C.

0.552 mm Hg at 25 deg C

A flammable liquid.

Henry's Law constant = 2.85X10-4 atm-cu m/mol at 25 °C (est)

Conversion factor: 1 ppm = 5.81 mg/cu m; 1 mg/L = 172 ppm|Hydroxyl radical reaction rate constant = 1.33X10-11 cu cm/molec-sec at 25 °C (est)

Highly flammable.

Ketones

Highly Flammable

Ketones, such as DI-N-BUTYL KETONE, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. May attack some forms of plastics (USCG, 1999).

A flammable liquid.

Ⅲ

3

UN 1224 3/PG 3

3

3

23-24/25

RA8230000

Xn: Harmful;

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P314, P337+P313, P370+P378, P403+P233, P403+P235, P405, P501

H226

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Fire Extinguishing Agents Not to Be Used: Water may be ineffective. Fire Extinguishing Agents: Foam, dry chemical, carbon dioxide (USCG, 1999)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Rubber gloves; goggles or face shield (USCG, 1999)

The major hazards encountered in the use and handling of dibutyl ketone stem from its toxicologic properties. Toxic by all routes (ie, inhalation, ingestion, and dermal contact), exposure to this colorless to light yellow liquid may occur from its presence as a contaminant in some solvents. Effects from exposure may include ocular pain and corneal damage, shortness of breath, nausea, headache, dizziness, fainting, coma and death. When heated to decomposition, dibutyl ketone emits acrid fumes. Before implementing land disposal of waste dibutyl ketone, consult with environmental regulatory agencies for guidance.

Dibutyl ketone has been qualitatively detected in trench leachates collected from commercially operated low-level radioactive waste disposal sites at Maxey Flats, KY and at West Valley, NY(1). Dibutyl ketone has been identified, not quantified, in wastewater effluents from domestic sewage treatment(2). Dibutyl ketone was detected in 2 of 63 industrial waters (concn less than 10 ppb) which were sampled from a wide range of chemical manufacturers in areas across the United States(3).

The toxicity of 5-nonanone in rats is enhanced by simultaneous exposure to the microsomal enzyme inducing agent methyl ethyl ketone.|An oral dose of 233 mg/kg 5-nonanone admin to rats 5 days/wk for 13 wk produced a minor subclinical neuropathy. When the same amt of 5-nonanone (233 mg/kg) was present as an 11% contaminant in a commercial lot of 5-methyl-2-octanone, neuropathy developed in less than 90 days.

/AQUATIC SPECIES/ Affected fish /fathead minnow/ became hypoactive, stopped schooling, and lost equilibrium prior to death. /Purity 98%/|/OTHER TERRESTRIAL SPECIES/ Ketones, incl dibutyl ketone, tested in releasing alarm pheromones in ants. The most active cmpd were of a size and geometry similar to 4-methyl-3-heptanone.

Dibutyl ketone's former production and use as a solvent(1) and as a byproduct during the synthesis of other ketones(2) may have resulted in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a water solubility of 363 mg/L(2) and a regression-derived equation(3), indicates that dibutyl ketone is expected to have moderate mobility in soil(SRC). Volatilization of dibutyl ketone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.8X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 0.55 mm Hg(4), and its water solubility(2). Dibutyl ketone is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Dibutyl ketone is expected to biodegrade under aerobic conditions(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a water solubility of 363 mg/L(2) and a regression-derived equation(3), indicates that dibutyl ketone is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 2.8X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 0.55 mm Hg(4), and its water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 7 hours and 5.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 22(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Dibutyl ketone is expected to biodegrade under aerobic conditions(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dibutyl ketone, which has a vapor pressure of 0.55 mm Hg at 25deg C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dibutyl ketone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 29 hours(SRC), calculated from its rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Dibutyl ketone contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of dibutyl ketone with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 29 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Dibutyl ketone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Dibutyl ketone contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight(2).

An estimated BCF of 22 was calculated in fish for dibutyl ketone(SRC), using a water solubility of 363 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of dibutyl ketone is estimated as 170(SRC), using a water solubility of 363 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dibutyl ketone is expected to have moderate mobility in soil.

The Henry's Law constant for dibutyl ketone is estimated as 2.8X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 0.55 mm Hg(1), and water solubility, 363 mg/L(2). This Henry's Law constant indicates that dibutyl ketone is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 7 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5.8 days(SRC). Dibutyl ketone's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Dibutyl ketone is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Dibutyl ketone was detected, not quantified, in the volatiles of cooked beef(1).

Occupational exposure to dibutyl ketone may occur through inhalation and dermal contact with this compound at workplaces where dibutyl ketone and other ketones are produced. (SRC)

5-Nonanone is absorbed from the gastrointestinal tract of the rat. ... Radioactivity excreted in the urine accounted for approx 50% of the dose after 72 hr.

Metabolic studies confirmed the in vivo conversion of 5-nonanone to 2,5-nonanedione, methyl-n-butyl ketone, and 2,5-hexanedione, the latter of which is the most active neurotoxic metabolite of n-hexane and methyl-n-butyl ketone. The neurotoxicities of n-hexane, methyl-n-butyl ketone, and 5-nonanone are linked by virtue of their metabolism to a gamma -diketone, 2,5-hexanedione.|Metabolic transformations incl omega-1 oxidation to 2,5-nonoanedione with subsequent oxidative and decarboxylative steps to produce methyl n-butyl ketone and 2,5-hexanedione. In addition, 5-nonanone is oxidized to carbon dioxide (38% of the dose). ... No unchanged 5-nonanone was detected in the urine, but both methyl n-butyl ketone and 2,5-hexanedione were present.

The toxicity of 5-nonanone appears to be directly related to its metabolic conversion to 2,5-hexanedione; thus its mechanism of action is expected to be similar to gamma-diketones.

Inhalation causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes or skin causes irritation. (USCG, 1999)

INHALATION: remove to fresh air; administer artificial respiration if needed. EYES: flush with water for at least 15 min. SKIN: flush with water. (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . For contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ketones and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ketones and related compounds/

/OTHER TOXICITY INFORMATION/ No adverse effects to humans due to 5-nonanone have been reported.

5-nonanone

5-Nonanone: ACTIVE

Analyte: 5-nonanone; matrix: food (honey); procedure: purge-and-trap gas chromatography with mass spectrometry detection|Analyte: 5-nonanone; matrix: air; procedure: atmospheric sampling Townsend discharge ionization mass spectrometry