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Azure B

Azure B structure

CAS No:
531-55-5
Formula:
C15H16N3S.Cl
Chemical Name:
Azure B
Synonyms:
Phenothiazin-5-ium,3-(dimethylamino)-7-(methylamino)-,chloride (1:1);Phenothiazin-5-ium,3-(dimethylamino)-7-(methylamino)-,chloride;Azure B;Trimethylthionine;C.I. 52010;Methylene Azure;Azure I;Azur I;3-Methylamino-7-dimethylaminophenazathionium chloride;Trimethylthionine chloride;Azure B chloride;2150-35-8;31754-60-6;856825-57-5;96730-31-3
Categories:
Biochemical Engineering > Biochemical Reagents

Description

Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2].

Azure B is an organic chloride salt having 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium as the counterion. It is used in making azure eosin stains for blood smear staining and is an active metabolite of methylene blue. It has a role as a histological dye, a fluorochrome, a drug metabolite, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 1.4.3.4 (monoamine oxidase) inhibitor, a cardioprotective agent and an antidepressant. It contains a 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium.

Azure B Basic Attributes

Molecular Weight：

305.83

Exact Mass：

305.075348

BRN：

3922630

EC Number：

208-511-2

UNII：

7C8BEL8WQV

NSC Number：

9598

DSSTox ID：

DTXSID7040158

HScode：

2934300000

Characteristics

PSA：

52.7

XLogP3：

-0.44840

Appearance：

Dark green Powder

Melting Point：

205-210 °C (dec.)(lit.)

Water Solubility：

H2O: soluble

Toxicity：

Intravenous injection-mouse LD50: 37.72 mg/kg

Flammability characteristics：

Solvent flammable

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

SO5550000

Storage features：

Treasury is ventilated, low temperature and dry; stored and transported separately from oxidant

Explosive characteristics：

Solvent mixed with air can be explosive

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H341

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH Entry Terms：

Azure B

Azure B Use and Manufacturing

Biological stain.

Computed Properties

Molecular Weight:305.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:305.0753464
Monoisotopic Mass:305.0753464
Topological Polar Surface Area:52.7
Heavy Atom Count:20
Complexity:498
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Azure B

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Azure B

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