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Ftivazide

Ftivazide structure

CAS No:
149-17-7
Formula:
C14H13N3O3
Chemical Name:
Ftivazide
Synonyms:
4-Pyridinecarboxylic acid,2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide;Isonicotinic acid,vanillylidenehydrazide;4-Pyridinecarboxylic acid,[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide;Ftivazid;Ftivazide;Phthivazid;Phthivazide;Vanicid;Vanillaberon;Vanizide;N-Isonicotinamido-3-methoxy-4-hydroxybenzalimine;NSC 31725
Categories:
Organic Chemistry > Hydrazine or Hydroxylamine Derivatives

Description

Ftivazide is a derivative of isoniazid, used to treat tuberculosis in the Soviet Union.|Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.

Ftivazide Basic Attributes

Molecular Weight：

271.275

Exact Mass：

271.27

UNII：

40Q4C3O4V0

NCI Thesaurus Code：

C72604

HScode：

2933399090

Characteristics

PSA：

80.3

XLogP3：

1.95060

Density：

1.2122 (rough estimate)

Melting Point：

219-220 °C

Boiling Point：

414.36°C (rough estimate)

Flash Point：

220.9ºC

Refractive Index：

1.5700 (estimate)

Drug Information

MeSH：

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some ANTINEOPLASTIC AGENTS and ANTI-OBESITY AGENTS and of some ANTI-INFECTIVE AGENTS which interfere with CELL WALL and CELL MEMBRANE formation. (See all compounds classified as Fatty Acid Synthesis Inhibitors.)|Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

MeSH Entry Terms：

Acid Vanillylidenehydrazide, Isonicotinic

Computed Properties

Molecular Weight:271.27
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:271.09569129
Monoisotopic Mass:271.09569129
Topological Polar Surface Area:83.8
Heavy Atom Count:20
Complexity:343
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes