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Buscopan

Buscopan structure

CAS No:
149-64-4
Formula:
C21H30NO4.Br
Chemical Name:
Buscopan
Synonyms:
3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-,bromide (1:1),(1α,2β,4β,5α,7β)-;1αH,5αH-Tropanium,8-butyl-6β,7β-epoxy-3α-hydroxy-,bromide,(-)-tropate;3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-,bromide,[7(S)-(1α,2β,4β,5α,7β)]-;N-Butylscopolammonium bromide;3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-,bromide,(1α,2β,4β,5α,7β)-;Tropic acid,(-)-,ester with 8-butyl-6β,7β-epoxy-3α-hydroxy-1αH,5αH-tropanium bromide;Buscapine;Buscopan;N-Butylhyoscine bromide;Scobutyl;Scopolamine butyl bromide;Buscolysine;Joscine;N-Butylhyoscinium bromide;Butylscopolamine bromide;Hyoscine butyl bromide;N-Butylscopolamine bromide;Scobutil;Butylscopolammonium bromide;Buscolysin;Scopolamine butobromide;Hyoscine butobromide;N-Butylscopolaminium bromide;Scopolamine-N-butyl bromide;Scopolamine bromobutylate;Amisepan;Buscol;Buscolamin;Butylmin;Donopon;Monospan;Scobro;Scobron;Sparicon;Sporamin;Stibron;Tirantil;Scopolan;(-)-Scopolamine butylbromide;Sporamin (pharmaceutical);127420-71-7;22626-85-3;38533-48-1;53832-48-7
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.Target: mAChRScopolamine (USAN), also known as levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed (Datura), angel's trumpets (Brugmansia), and corkwood (Duboisia). Scopolamine exer

Buscopan Basic Attributes

Molecular Weight：

440.37

Exact Mass：

439.135803

EC Number：

205-744-1

DSSTox ID：

DTXSID1022718

HScode：

2934999090

Characteristics

PSA：

59.06000

XLogP3：

-0.80420

Appearance：

white powder

Melting Point：

143 °C

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Toxicity：

Oral-Rat LD50 1040 mg/kg; Oral-Mouse LD50: 1170 mg/kg

Flammability characteristics：

Combustible, decomposes toxic nitrogen oxides and bromide gases when burned

Specific rotation：

D20 -20.8° (c = 3 in water)

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

YM3500000

Marks：

Storage features：

Warehouse low temperature, ventilated, dry

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Toxicity

Toxicity class：

moderately toxic

Buscopan Use and Manufacturing

Anticholinergic. Antispasmodic

Computed Properties

Molecular Weight:440.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:439.13582
Monoisotopic Mass:439.13582
Topological Polar Surface Area:59.1
Heavy Atom Count:27
Complexity:500
Defined Atom Stereocenter Count:3
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an M cholinergic receptor blocker, and its peripheral effects are similar to those of atropine. It has a stronger antispasmodic effect on smooth muscles than atropine, and can selectively relieve gastrointestinal, bile duct and urinary tract smooth muscle spasms and inhibit their peristalsis. It can also be used to relieve vascular smooth muscle spasms and improve microcirculation; its inhibitory effect on the secretion of glands such as the heart, eye smooth muscles (mydriasis and accommodation paralysis) and salivary glands is less than that of atropine, and side effects such as central nervous system excitement, mydriasis, and inhibition of saliva secretion caused by atropine rarely occur when used.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Scopolamine Butylbromide Tablets
Ingredients	The main ingredient of this product is scopolamine butylbromide. Molecular weight: C21H30BRNO4
Indication	① When used in combination with other anticholinergics, phenothiazines and other drugs, the toxicity will increase. ② It can antagonize the gastrointestinal motility-promoting effects of metoclopramide, domperidone and the like. ③ Certain antiarrhythmic drugs (such as quinidine, disopyramide, etc.) should be used with caution in combination with this product, because the former has the effect of blocking the vagus nerve, so it can enhance the anticholinergic effect of this product, leading to dry mouth, blurred vision, and dysuria. The elderly should pay special attention. ④ When this product is used in combination with adrenergic drugs (such as: dextroamphetamine 5mg), it can enhance the antiemetic effect and reduce the drowsiness of this product, but the dry mouth is more significant. ⑤ When used in combination with tricyclic antidepressants (amitriptyline, etc.), both have anticholinergic effects, and side effects such as dry mouth, constipation, and blurred vision are aggravated, which can cause urinary retention in elderly patients and induce acute glaucoma and paralytic intestinal
Specifications	10 mg

Scopolamine Butylbromide Tablets
Specifications	10mg

Scopolamine Butylbromide
Indication	1. When used in combination with other anticholinergics, phenothiazines and other drugs, it will increase toxicity; 2. It can antagonize the gastrointestinal motility-promoting effects of metoclopramide, domperidone and the like; 3. Certain antiarrhythmic drugs (such as quinidine, disopyramide, etc.) should be used with caution in combination with this product, because the former have the effect of blocking the vagus nerve, so they can enhance the anticholinergic effect of this product, leading to dry mouth, blurred vision, and dysuria, and the elderly should pay special attention to this; 4. When this product is used in combination with adrenergic drugs (such as: dextroamphetamine 5mg), it can enhance the antiemetic effect and reduce the drowsiness of this product, but the dry mouth is more significant; 5. When used in combination with tricyclic antidepressants (amitriptyline, etc.), both have anticholinergic effects, and side effects such as dry mouth, constipation, and blurred vision are aggravated, which can cause urinary retention in elderly patients and induce
Manufacturer	Yantai Luyin Pharmaceutical Co., Ltd.

Scopolamine Butylbromide

Indication

1. When used in combination with other anticholinergics, phenothiazines and other drugs, it will increase toxicity; 2. It can antagonize the gastrointestinal motility-promoting effects of metoclopramide, domperidone and the like; 3. Certain antiarrhythmic drugs (such as quinidine, disopyramide, etc.) should be used with caution in combination with this product, because the former have the effect of blocking the vagus nerve, so they can enhance the anticholinergic effect of this product, leading to dry mouth, blurred vision, and dysuria, and the elderly should pay special attention to this; 4. When this product is used in combination with adrenergic drugs (such as: dextroamphetamine 5mg), it can enhance the antiemetic effect and reduce the drowsiness of this product, but the dry mouth is more significant; 5. When used in combination with tricyclic antidepressants (amitriptyline, etc.), both have anticholinergic effects, and side effects such as dry mouth, constipation, and blurred vision are aggravated, which can cause urinary retention in elderly patients and induce

Manufacturer

Yantai Luyin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Anhui Gallup Pharmaceutical Technology Co., Ltd.

China
Active
Boehringer Ingelheim (China) Investment Co., Ltd.

China
Active
China CHINO PHARMA Ltd

China
Active

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