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Narwedine

Narwedine structure

CAS No:
510-77-0
Formula:
C17H19NO3
Chemical Name:
Narwedine
Synonyms:
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-,(4aS,8aS)-;Narwedine;Galanthamine,3-deoxy-3-oxo-;(4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one;Galanthaminone;(-)-Narwedine;Narwedin;1359-85-9;26601-10-5
Categories:
Organic Chemistry > Amides

Description

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Narwedine is a benzazepine.

Narwedine Basic Attributes

Molecular Weight：

285.34

Exact Mass：

285.34

EC Number：

610-608-3

UNII：

38CR9WB857

DSSTox ID：

DTXSID60168190

HScode：

2942000000

Characteristics

PSA：

38.8

XLogP3：

1.04

Appearance：

white to off-white chemical

Density：

1.3±0.1 g/cm3

Melting Point：

188-190 °C

Boiling Point：

397.4±42.0 °C at 760 mmHg

Flash Point：

194.1±27.9 °C

Refractive Index：

1.626

Storage Conditions：

-20°C Freezer

Safety Information

Precautionary statement(s)：

P264, P270, P273, P280, P301+P312, P305+P351+P338, P330, P337+P313, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P310, P302+P352, P304+P340, P311, P321, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P264, P270, P273, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, and P501

Drug Information

MeSH Entry Terms：

galanthaminone

Narwedine Use and Manufacturing

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Computed Properties

Molecular Weight:285.34
XLogP3:1.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:285.13649347
Monoisotopic Mass:285.13649347
Topological Polar Surface Area:38.8
Heavy Atom Count:21
Complexity:477
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Galanthaminone

CAS No.: 510-77-0

Content: 99.00%

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