Trimethyl phosphate

140.075

140.07

208-144-8

Z1E45TMW1Z

0686

58985

DTXSID1021403

Liquid|Colorless liquid

2919900090

54.57000

-0.52

Trimethyl phosphate appears as a pale straw colored liquid. Inhalation may irritate respiratory tract. Vapor or liquid may irritate skin or eyes. Ingestion may irritate the mucous membranes of the gastrointestinal tract.

1.2144 g/cm³ @ Temp: 20 °C

-46 °C

85 °C @ Press: 26 Torr

83.7±38.8 °C

1.379

500 G/L (25 ºC)

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully

1.133 hPa (25 °C)

LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rabbit 3388 mg/kg

The residue from a large scale atmospheric pressure distillation of trimethyl phosphate exploded violently. This was attributed to rapid decomposition of the ester, catalyzed by the acidic degradation products, with evolution of gaseous hydrocarbons. It is recommended that only small batches of alkyl phosphates should be vacuum distilled and in presence of magnesium oxide to neutralize any acid by-products, and to suppress the acid catalyzed reaction.

Pleasant smelling

7.37e-12 cm3/molecule*sec

7.20e-09 atm-m3/mole|Henry's Law constant = 7.2X10-9 atm-cu m/mole at 20 °C

22.1% phosphorus; pour point: -46 °C|Specific gravity: 1.97 at 19.5 °C/0deg C|Hydroxyl radical reaction rate constant = 7.37X10-12 cu cm/molec-sec at 25 °C|Hydroxyl radical reaction rate constant = <6X10-20 cu cm/molec-sec at 25 °C

Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

TRIMETHYL PHOSPHATE may explode when heated. Residue from a large scale atmospheric pressure distillation of this chemical has exploded violently. It is incompatible with nitrates. (NTP, 1992). Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

2810

1

R22;R40;R68

S53-S36/37-S45

TC8225000

Xn:Harmful;

Separated from strong oxidants and strong bases.

Stable under recommended storage conditions.

P201-P281-P305 + P351 + P338-P308 + P313

H302-H315-H319-H340-H351

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.

Incompatible materials: Strong oxidizing agents, strong bases.

Bioassay of Trimethylphosphate for Possible Carcinogenicity (1978) Technical Rpt Series No. 81 DHEW Pub No. (NIH) 78-1331, U.S. Department of Health Education and Welfare, National Cancer Institute, Bethesda, MD 20014

This chemical is nonflammable. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H302 (82.91%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P310, P314, P321, P330, P332+P313, P337+P313, P362, P405, and P501|Aggregated GHS information provided by 238 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, and P501|P201, P202, P260, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P309+P311, P314, P321, P330, P332+P313, P337+P313, P362, P405, and P501

Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Apply water spray or mist to knock down vapors. Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Neutralize with dilute caustic soda (NaOH) or soda ash (Na2CO3). Water spill: Use natural barriers or oil spill control booms to limit spill travel. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Remove trapped material with suction hoses. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/|Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Explodes when heat distilled.|The residue from a large scale atmospheric pressure distillation of trimethyl phosphate exploded violently. This was attributed to rapid decomposition of the ester, catalyzed by the acidic degradation products, with evolution of gaseous hydrocarbons. It is recommended that only small batches of alkyl phosphates should be vacuum distilled and in presence of magnesium oxide to neutralize any acid by-products, and to suppress the acid catalyzed reaction.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Special hazards arising from the substance or mixture: Carbon oxides, oxides of phosphorus.

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Avoidance of skin contact and inhalation of mist, dust, or vapor (esp if heated liquids are handled) will usually be desirable ... . /Phosphate esters/|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Normal measures for preventive fire protection.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Strong irritant to skin and eyes.

Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants and strong bases.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system.

The substance may have effects on the nervous system. This may result in flaccid paralysis. May cause heritable genetic damage to human germ cells.

NO open flames.

AVOID ALL CONTACT!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

Trimethyl phosphate was qualitatively identified in effluents discharged into the upper reaches of the River Lee in the United Kingdom from 2 sewage treatment facilities(1). Trimethyl phosphate was identified as a reaction product during the chlorination of terrestrial humic acid commonly used in the production of drinking water(2). Trimethyl phosphate was not detected in sludge samples taken from 11 sewage treatment plants located throughout Sweden, samples were collected 2002 to 2003(3). The concentration of trimethyl phosphate in influent and effluent samples taken concurrently from these same plants was <0.8-584 and <0.8-79 ng/L, respectively(3).

URBAN/SUBURBAN: Trimethyl phosphate was detected at 24 pg/cu m in Pallas, Finland; samples were collected Jul 2004(1).

Trimethyl phosphate was detected at 1.1 ng/sq m/day in deposition samples from Pallas, Finland; samples were collected Jul 2004(1).

IDENTIFICATION AND USE: Trimethyl phosphate is a colorless liquid. It is used as a gasoline additive for controlling surface ignition and spark plug fouling; methylating agent, chemical intermediate in the production of polymethyl polyphosphates; flame retardant solvent for paints and polymers; catalyst in the preparation of polymers and resins. HUMAN EXPOSURE AND TOXICITY: Weakness and paralysis are neurotoxic effects of trimethyl phosphate. ANIMAL STUDIES: Trimethyl phosphate was a rabbit eye irritant. In rabbits oral or dermal administration produced flaccid and spastic paralysis. Trimethyl phosphate was neurotoxic in beagle dogs. After 4 wk, neurotoxicity was noted in impairment of hopping, tactile placing, and atactic gait. Electrophysiologic tests indicated a prolonged latency of neuromuscular impulse transmission after wk 9, followed by a decrease in maximum conduction velocity of sensory fibers. Peripheral nerve fibers also had abnormalities at this time, including paranodal and internodal swelling, paranodal demyelination, and distal fragmentation. Trimethyl phosphate induced sterility in mice, rats and rabbits. Trimethyl phosphate primarily affected epididymal spermatozoa, probably by action of sperm motility. Trimethyl phosphate causes aspermia in D. melanogaster males. Evidence from cytological studies of larval testes suggests that the chemosterilizing effect of the chemical is upon early primary spermatocytes. In developmental studies in mice, F1 male progeny were sterile or semi-sterile, resulting from heritable translocations. Thus, trimethyl phosphate is capable of causing chromosomal damage in mouse spermatids. in NTP carcinogenicity studies trimethyl phosphate was associated with the induction of benign fibromas of the subcutaneous tissue in male Fischer rats. No evidence of carcinogenicity of the compound was obtained in female rats. Trimethylphosphate was carcinogenic in female mice, inducing adenocarcinomas of the uterus/endometrium. No evidence of carcinogenicity of the compound was obtained in male mice. ECOTOXICITY STUDIES: In Japanese quail treated orally with trimethyl phosphate, there was rapid decline in the percentage of fertile eggs during the 10 day period following the first dose. In another study it was reported that only 81% of eggs laid between 1 and 35 days after treatment of male quail with trimethyl phosphate were fertile, significantly less than in the control group .

LD50 Rabbit dermal 3388 mg/kg|LD50 Rat oral 840 mg/kg|LD50 Rabbit oral 1050 mg/kg|LD50 Mouse oral 1470 mg/kg|For more Non-Human Toxicity Values (Complete) data for TRIMETHYL PHOSPHATE (8 total), please visit the HSDB record page.

Trimethylphosphate is an alkylating agent which has been used as a gasoline additive, a methylating agent, an intermediate for the production of polymethyl phosphates, and a flame retardant in polymers. A bioassay of trimethylphosphate for possible carcinogenicity was conducted by administering the compound by gavage to Fischer 344 rats. ... Groups of 50 rats ... of each sex were administered trimethylphosphate in distilled water three times per week at one of two doses, either 50 or 100 mg/kg body weight. ... Vehicle controls consisted of groups of 20 rats ... of each sex. The rats were dosed for 104 weeks. ... All surviving rats were killed at week 105 and all surviving mice at week 103. Mean body weights of dosed male and female rats and female mice were slightly lower than those of the corresponding vehicle controls throughout the study; mean body weights of the male mice were comparable to those of the vehicle controls. Survival rates of rats ... were high, and adequate numbers of animals were at risk for the development of late-appearing tumors. In male rats, the incidence of fibromas of the subcutaneous tissue was higher (P=0.036) in the high-dose group than in the vehicle controls (control 0/20, low-dose 2/50, high-dose9/49), and there was a dose-related trend (P=0.006) in the incidences of these fibromas. In the female rats, no tumors occurred in the dosed groups at significantly increased incidences, compared with corresponding controls. ... Trimethylphosphate was associated with the induction of benign fibromas of the subcutaneous tissue in male Fischer 344 rats. No evidence of carcinogenicity of the compound was obtained in female rats. ...|Trimethylphosphate is an alkylating agent which has been used as a gasoline additive, a methylating agent, an intermediate for the production of polymethyl phosphates, and a flame retardant in polymers. A bioassay of trimethylphosphate for possible carcinogenicity was conducted by administering the compound by gavage to ... B6C3F1 mice. Groups of ... 50 mice of each sex were administered trimethylphosphate in distilled water three times per week at one of two doses, ... either 250 or 500 mg/kg body weight. ... Vehicle controls consisted of groups of ... 20 mice of each sex. The ... mice were dosed for 103 weeks. All ... surviving mice at week 103. Mean body weights of dosed ... female mice were slightly lower than those of the corresponding vehicle controls throughout the study; mean body weights of the male mice were comparable to those of the vehicle controls. Survival rates of ... mice were high, and adequate numbers of animals were at risk for the development of late-appearing tumors. ... In the male mice, no tumors occurred in the dosed groups at significantly increased incidences, compared with controls. In the female mice, the incidence of adenocarcinomas of the endometrium was higher (P=0.004) in the high-dose group than in the vehicle controls (controls 0/16, low-dose 7/40, high-dose 13/37), and there was a significant dose-related trend (P=0.003) in the incidences of these adenocarcinomas. It is concluded that under conditions of this bioassay, trimethylphosphate was carcinogenic in female B6C3F1 mice, inducing adenocarcinomas of the uterus/endometrium. ... No evidence of carcinogenicity of the compound was obtained in ... male mice.

Trimethyl phosphate's production and use as a gasoline additive, flame retardant solvent for paints and polymers, and as a stabilizer and antioxidant(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a structure estimation method(2), indicates that trimethyl phosphate is expected to have very high mobility in soil(SRC). Volatilization of trimethyl phosphate from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.2X10-9 atm-cu m/mole(3). Trimethyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.85 mm Hg at 25 °C(4). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is not a fast environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a structure estimation method(2), indicates that trimethyl phosphate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 7.2X10-9 atm-cu m/mole(4). The hydrolysis half-life of trimethyl phosphate is 120-900 days based on experimental hydrolysis rate constants(5-7). According to a classification scheme(8), BCFs of <1.4 and 0.2-0.4 reported in carp(9), suggest bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks(9) indicating that biodegradation is not a fast environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl phosphate, which has a vapor pressure of 0.85 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC); the half-lives for these reactions in air are estimated to be 52 hours and 190 days(SRC), calculated from its respective rate constants of 7.37X10-12(3) and <6X10-20(4) cu cm/molecule-sec at 25 °C. Trimethyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of trimethyl phosphate with photochemically-produced hydroxyl radicals has been reported as 7.37X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 52 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of trimethyl phosphate with ozone has been reported as <6X10-20 cu cm/molecule-sec at 25 °C(2). This corresponds to an atmospheric half-life of about 190 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(3). The hydrolysis rate constants of trimethyl phosphate in distilled water were determined to be 3.2X10-5/hr at 20 °C and 2.4X10-4/hr at 37 °C(4) which correspond to half-lives of about 900 and 120 days, respectively. Based on a second-order alkaline hydrolysis rate constant of 2X10-4 M/sec for trimethyl phosphate at 27 °C and pH 10(5), the half-life can be estimated to be about 400 days. Neutral and base-catalyzed hydrolysis rate constants were reported for trimethyl phosphate at 25 °C of 1.8X10-8/sec and 1.3X10- 4/sec, respectively(6). Based on this neutral hydrolysis rate constant, the hydrolysis half-life can be estimated to be 445 days(SRC). Trimethyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(7) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

1.41|BCFs of <1.4 and 0.2-0.4 were reported in carp (Cyprinus carpio) which were exposed to trimethyl phosphate at 0.2 and 2 ppb, respectively, over a 6-week period(1). Also reported in carp were values of 1.5-2.4 following 6-week exposure at 25 °C(2). According to a classification scheme(3), these BCFs suggest bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of trimethyl phosphate can be estimated to be 11(SRC). According to a classification scheme(2), this estimated Koc value suggests that trimethyl phosphate is expected to have very high mobility in soil.

The Henry's Law constant for trimethyl phosphate is 7.2X10-9 atm-cu m/mole(1). This Henry's Law constant indicates that trimethyl phosphate is expected to be essentially nonvolatile from water and moist soil surfaces(2). Trimethyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.85 mm Hg(3).

SURFACE WATER: Trimethyl phosphate was qualitatively detected in Japanese river water and seawater(1).|SNOW: Snow samples collected along a road, at an airport and 15 km from Umea Center, Sweden contained trimethyl phosphate at <0.9-10, 11-28 and <0.9 ng/kg, respectively; samples were collected Mar 2003(1).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of trimethyl phosphate is 1 to 99; the data may be greatly underestimated(1).|Occupational exposure to trimethyl phosphate may occur through inhalation and dermal contact with this compound at workplaces where trimethyl phosphate is produced or used. Monitoring and use data indicate that the general population may be exposed to trimethyl phosphate via inhalation of ambient air, and dermal contact with this compound or other consumer products containing trimethyl phosphate. (SRC)

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

Rats treated orally at 100 mg/kg and mice treated ip at 1000 mg/kg with (32)P-labeled trimethyl phosphate excreted primarily dimethyl phosphate in the urine. Only traces of the parent compound were detected, and only in the rats at less than 6 hr after treatment. S-Methyl cysteine and S-methyl cysteine N-acetate were also isolated. Small amounts of S-methyl glutathione were detected, presumably the initial methylation product in this series of metabolites ... . Metabolism of trimethyl phosphate was faster in the mouse than in the rat, but there was no evidence of further conversion to monomethyl phosphate in either species ... .

SYMPTOMS: Symptoms of exposure to this compound include strong irritation of the skin and eyes. Irritation of the mucous membranes and respiratory tract also occurs. ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion and inhalation. It is a strong irritant of the skin and eyes. It is also an irritant of the mucous membranes and respiratory tract. When heated to decomposition it emits toxic fumes of phosphorous oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Tri-Ortho-Cresyl Phosphate (TOCP) and Related Compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Tri-Ortho-Cresyl Phosphate (TOCP) and Related Compounds/|/SRP:/ Advanced treatment: Use proparacaine hydrochloride to assist eye irrigation ... . /Tri-Ortho-Cresyl Phosphate (TOCP) and Related Compounds/|/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|For more Antidote and Emergency Treatment (Complete) data for TRIMETHYL PHOSPHATE (6 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Weakness and paralysis are neurotoxic effects of trimethyl phosphate. /From table/

trimethyl phosphate

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Cough. Sore throat.

Redness.

Redness.

Petrochemical manufacturing|Phosphoric acid, trimethyl ester: ACTIVE|Trimethyl phosphate ... retards the velocity of a methane-oxygen flame with about the same molar efficiency as antimony trichloride.

Method: EPA-RCA 8270D; Procedure: gas chromatography/mass spectrometry; Analyte: trimethyl phosphate; Matrix: solid waste matrices, soils, air sampling media and water; Detection Limit: 10 ug/L.|A Versamid 900 column was claimed to be superior to other types of columns for gas chromatographic analysis of trimethyl phosphate and related compounds. Acidification of the aqueous medium, extraction with chloroform, and analysis with a thermionic detector gave a sensitivity of 0.1 ng.|EPA Method 1618: Determination of trimethyl phosphate using wide bore capillary column gas chromatography with electron capture detector.|Method: NIOSH 7905, Issue 2; Procedure: gas chromatography, phosphorus flame photometric detection; Analyte: phosphorus; Matrix: air; Detection Limit: 0.005 ug/sample. /Phosphorus/

An analytical method for the determination of 14 organophosphorus flame retardants (OPFRs), including halogenated OPFRs, non-halogenated OPFRs and triphenyl phosphine oxide (TPPO) in biological samples was developed using gas chromatography-mass spectrometry (GC/MS). Biological samples were extracted using microwave-assisted extraction (MAE) with hexane/acetone (1:1, v/v) as the solvent; then, a two-step clean-up technique, gel permeation chromatography (GPC) combined with solid phase extraction (SPE), was carried out before GC/MS analysis. Experimental results showed that the developed method efficiently removed the lipid compounds and co-extract interferences. Moreover, using the relatively "narrow" column (with an i.d. of 10 mm) significantly decreased the elution volume and, therefore, prevented the loss of the most volatile OPFRs, especially trimethyl phosphate (TMP) and triethyl phosphate (TEP). The method detection limits (MDLs) for OPFRs in the biological samples ranged from 0.006 to 0.021 ng g(-1) lw, and the recoveries were in the range of 70.3-111%, except for TMP (38.9-55.6%), with relative standard deviations (RSDs) of less than 14.1%. The developed method was applied to determine the amount of the target OPFRs in biological samples (i.e., fish and domestic birds) that were collected from the Pearl River Delta (PRD) region in southern China. Of the 14 OPFRs, tri-n-butyl phosphate (TnBP), tris(2-chloroethyl) phosphate (TCEP), tris(chloropropyl) phosphate (TCPP) and tributoxyethyl phosphate (TBEP) were present in all of the biological samples that were analyzed, and dominated by TnBP, TCEP and TBEP. The concentrations of OPFRs in the biological samples that were collected from the PRD region were higher than those reported in other locations.|Although O,O,O-trimethyl phosphate was not specifically included in the research, a gas chromatographic method developed ... for trimethyl phosphorothioates should be applicable for the analysis of the compound in animal tissues. The organophosphate is extracted from the biological sample with ethyl acetate and analyzed on a Carbowax 20M fused-silica capillary column with a specific nitrogen-phosphorus detector. The sensitivity attainable, measured in 0.1 ml aliquots of plasma or in 20 mg wet weight of tissue, should be 5 ng/sample ... .