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Homatropine hydrobromide

Homatropine hydrobromide structure

CAS No:
51-56-9
Formula:
C16H21NO3.BrH
Chemical Name:
Homatropine hydrobromide
Synonyms:
Benzeneacetic acid,α-hydroxy-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,hydrobromide (1:1);1αH,5αH-Tropan-3α-ol,mandelate (ester),hydrobromide;Benzeneacetic acid,α-hydroxy-,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,hydrobromide,endo-;Benzeneacetic acid,α-hydroxy-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,hydrobromide;Homatropine hydrobromide;Mandelic acid tropine ester hydrobromide;(±)-Homatropine bromide;Homatropine bromide;Isopto Homatropine
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication.Target: mAChRHomatropine is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs [1]. Homatropine has similar affinities for

Homatropine hydrobromide Basic Attributes

Molecular Weight：

356.25

Exact Mass：

355.07800

EC Number：

200-105-3

DSSTox ID：

DTXSID5045099

HScode：

2933990090

Characteristics

PSA：

49.77000

XLogP3：

2.78440

Appearance：

Colorless or white powder. Bromine-like odor.

Density：

1.21g/cm3

Melting Point：

250 °C (decomp)

Boiling Point：

434.9ºC at 760 mmHg

Flash Point：

216.8ºC

Water Solubility：

H2O: soluble

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Packing level：

I; II; III

Hazard category：

6.1

Transport codes：

1544

wgk germany：

hazard class code：

23/24/25

safety instructions：

45-24/25-22

RTECS Number：

YM5602000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

GHS Classification：

|Danger|H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P310, P301+P312, P302+P350, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P311, P312, P320, P321, P322, P330, P332+P313, P333+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Homatropine hydrobromide Use and Manufacturing

Uses

anticholinergic (opthalmic)

Manufacturing Info：

Benzeneacetic acid, .alpha.-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1): INACTIVE

Computed Properties

Molecular Weight:356.25
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:355.07831
Monoisotopic Mass:355.07831
Topological Polar Surface Area:49.8
Heavy Atom Count:21
Complexity:340
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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CAS No.: 51-56-9

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CAS No.: 51-56-9

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