trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate
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trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate
structure -
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CAS No:
51-77-4
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Formula:
C27H44O2
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Chemical Name:
trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate
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Synonyms:
4,8,12-Tetradecatrienoic acid,5,9,13-trimethyl-,(2E)-3,7-dimethyl-2,6-octadien-1-yl ester,(4E,8E)-;4,8,12-Tetradecatrienoic acid,5,9,13-trimethyl-,3,7-dimethyl-2,6-octadienyl ester,(E,E,E)-;4,8,12-Tetradecatrienoic acid,5,9,13-trimethyl-,(2E)-3,7-dimethyl-2,6-octadienyl ester,(4E,8E)-;trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate;Gefarnate;5,9,13-Trimethyl-4,8,12-tetradecatrienoic acid 3,7-dimethyl-2,6-octadienyl ester;Geranyl farnesylacetate;DA 688;Gefarnil;Gefarnyl;Gefanil;Alsanate;Dixnalate;Salanil;Gefulcer;Arsanyl;Zackal;Osteol;30462-47-6
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CAS No:
Description
Gefarnate is a drug used for the treatment of gastritis and gastric ulcer, and has been proposed for use in the treatment of dry eye syndrome.
trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate Basic Attributes
400.63706
400.64
200-121-0
trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate Use and Manufacturing
The 10.3g of farnesylacetic acid, 15.0g the geraniol, 25.0 ml of xylene, 0.43g of hydroquinone was mixed and refluxed for about 10 hours, to TLC (P/E = 25:1) detecting product characterized, using TLC (P/E=5:1) detecting whether the raw material is farnesyl acetate reaction is complete. Reaction end to obtain orange-yellow transparent mixed solution, after slightly cooling, decompression boil off b toluene; residues using normal hexane and 1 wt percent sodium hydroxide solution to extraction 2-3 time, separating, drying, boil off some solvent, good joining processing the remaining portions of the anhydrous calcium chloride stirring the mixture at room temperature for overnight, filtering and collecting the filtrate, concentrated to obtain gefarnate ester crude product. Crude characterized by reduced pressure distillation, collecting 186-200 °C distillation, gefarnate ester product is characterized.
Drug Function and Efficacy
Protect gastric mucosa, promote ulcer repair and healing, increase gastric mucosal prostaglandins, prevent low mucosal potential difference, promote soluble mucus secretion, increase visible mucus layer thickness, strengthen gastric mucosal barrier, expand gastric mucosal microcirculation, and improve blood flow distribution
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trans-3,7-Dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate
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