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Benzhexol hydrochloride

Benzhexol hydrochloride structure

CAS No:
52-49-3
Formula:
C20H31NO.ClH
Chemical Name:
Benzhexol hydrochloride
Synonyms:
TRIHEXYLPHENIDYL HYDROCHLORIDE;1-phenyl-1-cyclohexyl-3-piperidyl-1-propanolhydrochloride;3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanolhydrochloride;alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanohydrochloride;artanehydrochloride;benzhexolchloride;cyclodol;pacitane
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.

Trihexyphenidyl hydrochloride is an aralkylamine.|One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

Trihexyphenidyl is an antagonist of M1muscarinic acetylcholine receptors. It binds to rat M1receptors in cerebral cortex selectively over rat M2receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50= 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.

Benzhexol hydrochloride is White Solid

ChEBI: Trihexyphenidyl hydrochloride is an aralkylamine.

Benzhexol hydrochloride Basic Attributes

Molecular Weight：

337.93

Exact Mass：

337.217255

EC Number：

200-142-5

NSC Number：

757357

DSSTox ID：

DTXSID8045802

Color/Form：

white

HScode：

2933399090

Characteristics

PSA：

23.47000

XLogP3：

5.07040

Appearance：

white solid

Density：

0.9801 (rough estimate)

Melting Point：

Free base, mp 114.3-115.0°

Boiling Point：

447.9ºC at 760mmHg

Flash Point：

211ºC

Refractive Index：

1.5790 (estimate)

Water Solubility：

670.9ug/L(22.5 ºC)

Toxicity：

TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84

Flammability characteristics：

Combustion produces toxic nitrogen oxides and hydrogen chloride fumes; drug side effects: misinterpretation, hallucinations, eye diseases, confusion

Collision Cross Section：

174.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Critical Temperature & Pressure：

Inert atmosphere,Room Temperature

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

TN2625000

Marks：

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

RIDADR：

3249

GHS Classification：

|Danger|H301 (22.22%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P272, P280, P281, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 9 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

MeSH Entry Terms：

Apo Trihex

Benzhexol hydrochloride Use and Manufacturing

Uses

anticholinergic, antiparkinsonian

Benzhexol hydrochloride is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. The drug is a muscarinic anta gonist that qualitatively resembles the belladonna alkaloids in its pharmacological actions and side effects.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:337.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:337.2172423
Monoisotopic Mass:337.2172423
Topological Polar Surface Area:23.5
Heavy Atom Count:23
Complexity:314
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract the name, type (main ingredient or excipient), content, unit, and pharmacological action of the raw material from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Benhexyphenidyl hydrochloride tablets
Ingredients	The main ingredient of this product is trihexyphenidyl hydrochloride. Chemical name: (±)-α-cyclohexyl-α-phenyl-1-piperidinylpropanol hydrochloride Molecular weight: C20H31NO·HCl
Indication	1. When this product is used in combination with ethanol or other central nervous system depressants, the central inhibitory effect can be enhanced. 2. When this product is used in combination with adamantane, anticholinergic drugs, monoamine oxidase inhibitors pargyline and procarbazine, the anticholinergic effect can be enhanced and paralytic ileus may occur. 3. When this product is used in combination with monoamine oxidase inhibitors, it can lead to hypertension. 4. When this product is used in combination with antacids or adsorbent antidiarrheal agents, the effect of this product can be weakened. 5. When this product is used in combination with chlorpromazine, the latter's metabolism is accelerated, which can reduce its blood drug concentration. 6. When this product is used in combination with cardiac glycosides, the latter can prolong their residence time in the gastrointestinal tract, increase absorption, and be prone to poisoning.
Specifications	2mg*100s
Manufacturer	Tianjin Lisheng Pharmaceutical Co., Ltd.

Benhexyphenidyl hydrochloride tablets
Ingredients	The main ingredient of this product is: benzhexol hydrochloride. Its chemical name is: ?-cyclohexyl-a-phenyl-1-piperidinylpropanol hydrochloride
Indication	(1) When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect can be enhanced. (2) When this product is used in combination with adamantane, anticholinergic drugs, monoamine oxidase inhibitors such as pargyline and procarbazine, the anticholinergic effect can be enhanced and paralytic ileus can occur. (3) When this product is used in combination with monoamine oxidase inhibitors, it can cause hypertension. (4) When this product is used in combination with antacids or adsorbent antidiarrheal agents, the effect of this product can be weakened. (5) When this product is used in combination with chlorpromazine, the latter's metabolism is accelerated, which can reduce its blood drug concentration. (6) When this product is used in combination with cardiac glycosides, the latter can prolong their residence time in the gastrointestinal tract, increase absorption, and be prone to poisoning.
Specifications	2mg
Manufacturer	Shanxi Linfen Jianmin Pharmaceutical Factory Co., Ltd.

Benhexyphenidyl hydrochloride tablets
Ingredients	The main ingredients of this product are: Benhexyphenidyl hydrochloride
Indication	1. When this product is used in combination with ethanol or other central nervous system depressants, the central inhibitory effect can be enhanced. 2. When this product is used in combination with adamantane, anticholinergic drugs, monoamine oxidase inhibitors such as pargyline and procarbazine, the anticholinergic effect can be enhanced and paralytic ileus may occur. 3. When this product is used in combination with monoamine oxidase inhibitors, it can lead to hypertension. 4. When this product is used in combination with antacids or adsorbent antidiarrheal agents, the effect of this product can be weakened. 5. When this product is used in combination with chlorpromazine, the latter's metabolism is accelerated, which can reduce its blood drug concentration. 6. When this product is used in combination with cardiac glycosides, the latter can prolong their residence time in the gastrointestinal tract, increase absorption, and be prone to poisoning.
Specifications	2 mg
Manufacturer	Jiangsu Tasly DIYI Pharmaceutical Co., Ltd.

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Registered Holders

NATCO PHARMA LTD

Brazil
Active
OLON S.P.A.

Italy
Active
Beijing ZenYi Pharma-Tech Ltd.

China
Active

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