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(+)-Euphol

(+)-Euphol structure

CAS No:
514-47-6
Formula:
C30H50O
Chemical Name:
(+)-Euphol
Synonyms:
Lanosta-8,24-dien-3-ol,(3β,13α,14β,17α)-;13α,14β,17βH-Lanosta-8,24-dien-3β-ol;Euphol;(3β,13α,14β,17α)-Lanosta-8,24-dien-3-ol;Euphadienol;Eupha-8,24-dienol;5α-Eupha-8,24-dien-3β-ol;(+)-Euphol;Eupha-8,24-dien-3β-ol;(+)-Eupha-8,24-dien-3β-ol;NSC 36571;α-Euphol;13879-03-3
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1].

(+)-Euphol Basic Attributes

Molecular Weight：

426.717

Exact Mass：

426.72

NSC Number：

403164|36571

Characteristics

PSA：

20.23000

XLogP3：

11.00

Density：

1.0±0.1 g/cm3

Melting Point：

116 °C

Boiling Point：

498.9±44.0 °C at 760 mmHg

Flash Point：

221.1±20.7 °C

Refractive Index：

1.530

Drug Information

MeSH Entry Terms：

8,24-euphadien-3 beta-ol

(+)-Euphol Use and Manufacturing

antineoplastic, antiproliferative, antiinflammatory, antinociceptive

Computed Properties

Molecular Weight:426.7
XLogP3:8.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:426.386166214
Monoisotopic Mass:426.386166214
Topological Polar Surface Area:20.2
Heavy Atom Count:31
Complexity:767
Undefined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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