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Docusate calcium

Docusate calcium structure

CAS No:
128-49-4
Formula:
C20H38O7S.¹/2Ca
Chemical Name:
Docusate calcium
Synonyms:
Butanedioic acid,2-sulfo-,1,4-bis(2-ethylhexyl) ester,calcium salt (2:1);Succinic acid,sulfo-,1,4-bis(2-ethylhexyl) ester,calcium salt;Butanedioic acid,sulfo-,1,4-bis(2-ethylhexyl) ester,calcium salt;Dioctyl calcium sulfosuccinate;Sulfosuccinic acid,bis(2-ethylhexyl) ester,calcium salt;Surfak;Bis(2-ethylhexyl) calcium sulfosuccinate;Calcium di-2-ethylhexyl sulfosuccinate;Calcium dioctyl sulfosuccinate;Bis(2-ethylhexyl) sulfosuccinic acid calcium salt;Doxical;Docusate calcium;Calcium bis(2-ethylhexyl) sulfosuccinate;Di(2-ethylhexyl) sulfosuccinate calcium salt (2:1)
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Docusate Calcium is the calcium salt of docusate, a dioctyl salt and an emollient laxative with stool-softening activity. Docusate decreases surface tension and emulsification of fecal matter and allows water to penetrate and mix with stool. As a result, it softens the stool.|All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.

Docusate calcium Basic Attributes

Molecular Weight：

883.21500

Exact Mass：

882.41500

EC Number：

204-889-8

UNII：

6K7YS503HC

DSSTox ID：

DTXSID2044212

NCI Thesaurus Code：

C28999

HScode：

2917190090

Characteristics

PSA：

236.36000

XLogP3：

9.78060

Safety Information

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 75 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)

MeSH Entry Terms：

Aerosol OT

Computed Properties

Molecular Weight:883.2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:34
Exact Mass:882.4145902
Monoisotopic Mass:882.4145902
Topological Polar Surface Area:236
Heavy Atom Count:57
Complexity:526
Undefined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It works by promoting water-lipid mixing in the intestines to soften feces, is indicated for the treatment of chronic constipation and relief of constipation caused by iron supplements, and is used in conditions such as post-rectal surgery defecation difficulties and prevention of constipation in cardiovascular patients. It is contraindicated in intestinal obstruction and acute abdomen.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

DOCUSATE CALCIUM 240 MG SODIUM FREE- docusate calcium_capsule, liquid filled
Manufacturer	National Vitamin Company

Recommended Suppliers of Docusate calcium

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

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5 YRS

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128-49-4

CAS No.: 128-49-4

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