Sennoside B
-
Sennoside B
structure -
-
CAS No:
128-57-4
-
Formula:
C42H38O20
-
Chemical Name:
Sennoside B
-
Synonyms:
[9,9′-Bianthracene]-2,2′-dicarboxylic acid,5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-,(9R,9′S)-;Sennoside B;[9,9′-Bianthracene]-2,2′-dicarboxylic acid,5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-,(R*,S*)-;(9R,9′S)-5,5′-Bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo[9,9′-bianthracene]-2,2′-dicarboxylic acid;1344-35-0
- Categories:
-
CAS No:
Description
Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2].
Solid
Sennoside B is a member of the class of sennosides that is (9R,9'S)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. It is a member of sennosides and an oxo dicarboxylic acid.
Characteristics
348
1.2
Solid
1.7±0.1 g/cm3
1144.8ºC at 760 mmHg
348.6±27.8 °C
1.763
1e+006 mg/L @ 25 °C (est)
0mmHg at 25°C
D20 -100° (c = 0.2 in 70% acetone); D20 -67° (c = 0.4 in 70% dioxane)
Safety Information
NONH for all modes of transport
22
22-45-24/25
P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P321, P330, P333+P313, P342+P311, P363, P501
H302
|Danger|H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Sennoside B Use and Manufacturing
The pharmacological effect of sennoside B is similar to sennoside A, and it has a diarrhea effect.
Polyketides [PK] -> Aromatic polyketides [PK13] -> Anthracenes and phenanthrenes [PK1304]
Computed Properties
Molecular Weight:862.7
XLogP3:1.2
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:9
Exact Mass:862.19564360
Monoisotopic Mass:862.19564360
Topological Polar Surface Area:348
Heavy Atom Count:62
Complexity:1550
Defined Atom Stereocenter Count:12
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Laxative effect by stimulating colonic motility and inhibiting water and electrolyte reabsorption in the intestine
Recommended Suppliers of Sennoside B
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
danshenol B
189308-09-6
-
decarestrictine B
127393-91-3
-
decatromicin B
235097-64-0
-
Galactopinitol B Formula
88199-72-8
-
demethylxestospongine B Formula
144789-03-7
-
Saquayamycin B Formula
99260-67-0
-
Fumitremorgin B Structure
12626-17-4
-
dehydrobruceine B Structure
53730-90-8
-
What is (-)-6-Deoxyerythronolide B
15797-36-1
-
What is cyanosafracin B
96996-50-8