Galangin
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Galangin
structure -
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CAS No:
548-83-4
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Formula:
C15H10O5
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Chemical Name:
Galangin
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Synonyms:
4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-phenyl-;Galangin;Flavone,3,5,7-trihydroxy-;3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one;Norizalpinin;3,5,7-Trihydroxyflavone;NSC 407229;3,5,7-Trihydroxy-2-phenylchromen-4-one;3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one;50306-94-0
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CAS No:
Description
Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
Solid
Galangin is a 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells. It has a role as an antimicrobial agent, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor and a plant metabolite. It is a trihydroxyflavone and a 7-hydroxyflavonol.
Galangin Basic Attributes
270.24
270.24
272179
208-960-4
142FWE6ECS
407229
DTXSID70203288
2914400090
Characteristics
87
2.3
Solid
1.6±0.1 g/cm3
214.5 °C
518.6°C at 760 mmHg
202.0±23.6 °C
1.748
571.9 mg/L @ 25 °C (est)
154.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
36/37/38
26-37/39
LK9275500
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (95.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)
Galangin has known human metabolites that include (2S,3S,4S,5R)-6-(3,5-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid, (2S,3S,4S,5R)-6-(5,7-dihydroxy-4-oxo-2-phenylchromen-3-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid, and Kaempferol.
galangin
Galangin Use and Manufacturing
Galangin is a flavanoid found in Alpinia officinarum, galangal rhizome (Alpinia galanga) and in propolis. Galangin has been show to inhibit proliferation of estrogen receptor-positive MCF-7 human breast cancer cells as well as delay of mammary tumorigenesis.
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:270.24
XLogP3:2.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:270.05282342
Monoisotopic Mass:270.05282342
Topological Polar Surface Area:87
Heavy Atom Count:20
Complexity:424
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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