Amitriptyline hydrochloride
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Amitriptyline hydrochloride
structure -
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CAS No:
549-18-8
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Formula:
C20H23N.ClH
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Chemical Name:
Amitriptyline hydrochloride
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Synonyms:
1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-,hydrochloride (1:1);5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine,10,11-dihydro-N,N-dimethyl-,hydrochloride;1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-,hydrochloride;Amitriptyline hydrochloride;10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine hydrochloride;5-(3-Dimethylaminopropylidene)dibenzo[a,d][1,4]cycloheptadiene hydrochloride;Tryptizol;Saroten;Damilen hydrochloride;Amitriptyline chloride;Lentizol;Laroxyl;Sarotex;NIH 10794;Elavil;Amineurin;Uxen;Noriline;Triptizol;Domical;Miketorin;Amilent;Endep;Amiprin;Apo-Amitriptyline;Larozyl;Amicen;Saroten Retard;Pinsaun;Amitrip;Tryptine;Etravil;Amyline;Anapsique;Tryptal;Trynol;Tridep;Amilit;Amiplin;Novoprotect;Elatrol;Tripta;Trepiline;Redomex;Elatrolet;Vanatrip;Syneudon;Trytomer;Pinsanu;Teperin;Enafon;Adepril;Tryptanol;Lantron;Amyzol;Sarotena;Euplit;Amitril;Ro 4-1575;Deprex;Sylvemid;Amitid;Amil 25;ADT;[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine hydrochloride;8058-15-9
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CAS No:
Description
Amitriptyline Hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).Target: OthersAmitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter. It has negligible influence on the dopamine transporter and therefore does not affect dopamine reuptake, being nearly 1,000 times weaker on it than on serotonin [1]. Amitriptyline additionally functi
Amitriptyline hydrochloride is an organic tricyclic compound.|Limbitrol is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.|Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Amitriptyline hydrochloride Basic Attributes
313.86
313.159729
208-964-6
26LUD4JO9K
2744
755869|169910|104210
DTXSID9033187
C28819
29214990
Characteristics
3.2
white to off-white powder
1.076g/cm3
196-197 °C
398.2°C at 760 mmHg
11 °C
H2O: soluble
2-8°C
3.62X10-7 mm Hg at 25 deg C (est)
LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe)
166.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
III
6.1(b)
UN 2811 6.1/PG 3
3
23/24/25-36/37/38-42/43-63-39/23/24/25-11-50/53-36-22
22-26-36/37/39-45-36/37-16-61-60-7
HO9450000
T,F,N,Xn
Stable under recommended storage conditions. /Amitriptyline hydrochloride/
P210-P260-P280-P301 + P310-P311
H225-H301 + H311 + H331-H370
|Danger|H301 (67.52%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P263, P264, P270, P273, P280, P281, P301+P310, P301+P312, P305+P351+P338, P307+P311, P308+P313, P310, P321, P330, P337+P313, P391, P405, and P501|Aggregated GHS information provided by 118 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)|Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)
Amineurin
Chlordiazepoxide|Librium, Libritabs, Limbitrol, SK-Lygen|2744|Schedule IV - Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|No
Amitriptyline hydrochloride Use and Manufacturing
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1): INACTIVE
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:313.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:313.1597275
Monoisotopic Mass:313.1597275
Topological Polar Surface Area:3.2
Heavy Atom Count:22
Complexity:331
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a tricyclic antidepressant, which works by inhibiting the reuptake of 5-hydroxytryptamine and norepinephrine. It has a stronger inhibition on the reuptake of 5-hydroxytryptamine, and also has stronger sedative and anticholinergic effects.
Registered Holders
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MANKIND PHARMA LTD
Active
United States
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Vasudha Pharma Chem Ltd
Active
United States
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RL FINE CHEM PVT LTD
Active
United States
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