D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride
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![D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/324eced451c34810bb6736885125609f.png "D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride")
D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride
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CAS No:
551-74-6
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Formula:
C10H22Cl2N2O4.2ClH
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Chemical Name:
D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride
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Synonyms:
D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-,dihydrochloride;Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-,dihydrochloride,D-;Degranol;Mannomustine dihydrochloride;1,6-Bis(chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride;1,6-Bis[(2-chloroethyl)amino]-1,6-dideoxy-D-mannitol dihydrochloride;1,6-Bis(β-chlorethylamino)-1,6-didesoxy-D-mannitol dihydrochloride;Mannitol mustard dihydrochloride;Mannomustine hydrochloride;NSC 9698;Degranol chinoin;Dimesylmannitol hydrochloride;1187-01-5;8055-15-0;1195573-61-5
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CAS No:
Description
Mannomustine dihydrochloride is an organic molecular entity.|Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.
D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride Basic Attributes
378.112
376.04900
UOZ2JJZ3I5
Characteristics
105
0.47260
240-242 °C
541.9ºC at 760 mmHg
281.5ºC
5.27E-14mmHg at 25°C
LD50 i.v. in rats: 56 mg/kg (Scherf)
Drug Information
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) (See all compounds classified as Antineoplastic Agents, Alkylating.)
Decranol
Computed Properties
Molecular Weight:378.1
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:378.046068
Monoisotopic Mass:376.049018
Topological Polar Surface Area:105
Heavy Atom Count:20
Complexity:183
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride
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