 Home > Encyclopedia > (+)-Costunolide

(+)-Costunolide

(+)-Costunolide structure

CAS No:
553-21-9
Formula:
C15H20O2
Chemical Name:
(+)-Costunolide
Synonyms:
Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-;Germacra-1(10),4,11(13)-trien-12-oic acid,6α-hydroxy-,γ-lactone,(E,E)-;Costunolide;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-,[3aS-(3aR*,6E,10E,11aS*)]-;(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one;Costus lactone;Costunolid;(+)-Costunolide;NSC 106404;126621-28-1;11028-78-7;25333-06-6;46814-17-9;62458-56-4;80750-19-2
Categories:
Natural Products > Terpenes

Description

Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.IC50 Value: 6.2 - 9.8 ug/mL(sarcoma cells viability)[3]Target: Apoptosis inducerin vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. Howev

(+)-Costunolide Basic Attributes

Molecular Weight：

232.32

Exact Mass：

232.32

HScode：

29322090

Characteristics

PSA：

26.3

XLogP3：

3.55080

Appearance：

white to beige

Density：

1.0±0.1 g/cm3

Melting Point：

106-107 °C

Boiling Point：

385.4±42.0°C at 760 mmHg

Flash Point：

162.0±25.3 °C

Refractive Index：

1.519

Water Solubility：

DMSO: soluble 10mg/mL (clear solution)

Storage Conditions：

Store at -20°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-24/25

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H317-H319-H335

GHS Classification：

|Warning|H315 (97.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(+)-Costunolide Use and Manufacturing

Costus lactone can excite or inhibit the gastrointestinal tract.

Computed Properties

Molecular Weight:232.32
XLogP3:2.1
Hydrogen Bond Acceptor Count:2
Exact Mass:232.146329876
Monoisotopic Mass:232.146329876
Topological Polar Surface Area:26.3
Heavy Atom Count:17
Complexity:401
Defined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (+)-Costunolide

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity Costunolide CAS 553-21-9

CAS No.: 553-21-9

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Costunolide

Unit Price: nullnull /null null

CAS No.: 553-21-9

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Costunolide 99% see COA kanbei

CAS No.: 553-21-9

Grade: Industrial Grade

Content: 99%

Inquiry

Learn More Other Chemicals

1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione

77769-21-2
(1R,8R,10S)-3,8-dimethyl-5,9,15-trioxatetracyclo[11.2.1.02,6.08,10]hexadeca-2(6),3,13(16)-trien-14-one

20082-45-5
Olean-13(18)-en-3-ol, 3-acetate, (3β)-

51361-60-5
MelilotigeninB Formula

91269-84-0
Forrestin A Formula

152175-76-3
(13E)-15-Hydroxy-8(17),13-labdadiene-19-al Formula

3650-31-5
Lup-20(29)-ene-3α,23-diol Structure

32451-85-7
Trichokaurin Structure

23811-50-9
What is Communic acid

2761-77-5
What is Cuniloside B

1187303-40-7

Hot Searches: food grade defoamers; crude glycerine; n-isopropylbenzylamine for sale; hdpe prices; sodium acetate sds; methyl ethyl ketone for sale

Guide of (+)-Costunolide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

(+)-Costunolide

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.