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(+)-Costunolide

(+)-Costunolide structure

CAS No:
553-21-9
Formula:
C15H20O2
Chemical Name:
(+)-Costunolide
Synonyms:
Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-;Germacra-1(10),4,11(13)-trien-12-oic acid,6α-hydroxy-,γ-lactone,(E,E)-;Costunolide;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-,[3aS-(3aR*,6E,10E,11aS*)]-;(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one;Costus lactone;Costunolid;(+)-Costunolide;NSC 106404;126621-28-1;11028-78-7;25333-06-6;46814-17-9;62458-56-4;80750-19-2
Categories:
Natural Products > Terpenes

Description

Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.IC50 Value: 6.2 - 9.8 ug/mL(sarcoma cells viability)[3]Target: Apoptosis inducerin vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. Howev

(+)-Costunolide Basic Attributes

Molecular Weight：

232.32

Exact Mass：

232.32

HScode：

29322090

Characteristics

PSA：

26.3

XLogP3：

3.55080

Appearance：

white to beige

Density：

1.0±0.1 g/cm3

Melting Point：

106-107 °C

Boiling Point：

385.4±42.0°C at 760 mmHg

Flash Point：

162.0±25.3 °C

Refractive Index：

1.519

Water Solubility：

DMSO: soluble 10mg/mL (clear solution)

Storage Conditions：

Store at -20°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-24/25

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H317-H319-H335

GHS Classification：

|Warning|H315 (97.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(+)-Costunolide Use and Manufacturing

Costus lactone can excite or inhibit the gastrointestinal tract.

Computed Properties

Molecular Weight:232.32
XLogP3:2.1
Hydrogen Bond Acceptor Count:2
Exact Mass:232.146329876
Monoisotopic Mass:232.146329876
Topological Polar Surface Area:26.3
Heavy Atom Count:17
Complexity:401
Defined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (+)-Costunolide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Costunolide

CAS No.: 553-21-9

Content: 99.00%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

Costunolide;

Unit Price: $10 /G EXW

CAS No.: 553-21-9

Grade: Pharmaceutical grade

Content: 99%

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Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Costunolide 99% see COA kanbei

CAS No.: 553-21-9

Grade: Industrial Grade

Content: 99%

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Guide of (+)-Costunolide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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(+)-Costunolide

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