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Larocainehydrochloride

Larocainehydrochloride structure

CAS No:
553-63-9
Formula:
C16H26N2O2.ClH
Chemical Name:
Larocainehydrochloride
Synonyms:
LarocaineHCl;diMethocainehcl;Larocainehydrochloride;Dimethocainehydrochloride;DiethylaMinoneopentylAlcoholHydrochloridep-AMinobenzoate;3-DiethylaMino-2,2-diMethylpropylp-aMinobenzoateHydrochloride;1-AMinobenzoyl-2,2-diMethyl-3-diethylaMinopropanolHydrochloride;3-(DiethylaMino)-2,2-diMethyl-1-propanol1-(4-aMinobenzoate)HCl;3-(DiethylaMino)-2,2-diMethylpropyl4-aMinobenzoatehydrochloride;3-(Diethylamino)-2,2-dimethyl-1-propanol4-aminobenzoatehydrochloride
Categories:
Organic Chemistry > Amides

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Description

Off-White Solid

Larocainehydrochloride Basic Attributes

Molecular Weight：

314.851

Exact Mass：

314.176117

UNII：

Z768GH360Q

HScode：

2922499990

Characteristics

PSA：

55.56000

XLogP3：

4.17680

Density：

1.035g/cm3

Melting Point：

196-197ºC

Boiling Point：

403.5ºC at 760 mmHg

Flash Point：

197.8ºC

Toxicity：

MLD in mice, rabbits (g/kg): 0.30, 0.15 s.c.; 0.04, 0.015 i.v. (Hirschfelder, Bieter)

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

3-(diethylamino)-2,2-dimethylpropyl 4-aminobenzoate

Larocainehydrochloride Use and Manufacturing

Dimethocaine Hydrochloride is a local anesthetic, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 μM comparable to that of cocaine (IC50 = 0.7 μM). As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys. This product is intended for forensic and research purposes.[Cayman Chemical] A local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500).

Computed Properties

Molecular Weight:314.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:314.1761058
Monoisotopic Mass:314.1761058
Topological Polar Surface Area:55.6
Heavy Atom Count:21
Complexity:293
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes