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Trimethobenzamide hydrochloride

Trimethobenzamide hydrochloride structure

CAS No:
554-92-7
Formula:
C21H28N2O5.ClH
Chemical Name:
Trimethobenzamide hydrochloride
Synonyms:
Benzamide,N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-,hydrochloride (1:1);Benzamide,N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxy-,monohydrochloride;Benzamide,N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-,monohydrochloride;Benzamide,N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxy-,hydrochloride;N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide hydrochloride;4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine hydrochloride;Tigan hydrochloride;Trimethobenzamide hydrochloride;Tigan;Ro 2-9578;Xametina;Anaus
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

Trimethobenzamide Hydrochloride is the hydrochloride salt form of trimethobenzamide, a benzamide derivative with an antiemetic property. Although the mechanism of action is largely unknown, it inhibits the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center, thereby suppressing nausea and vomiting.

Trimethobenzamide hydrochloride Basic Attributes

Molecular Weight：

424.92

Exact Mass：

424.17600

EC Number：

209-075-6

UNII：

WDQ5P1SX7Q

NSC Number：

757359|37882

DSSTox ID：

DTXSID7047774

NCI Thesaurus Code：

C29522

HScode：

2924299090

Characteristics

PSA：

69.3

Density：

1.131g/cm3

Melting Point：

187.5-190 °C

Collision Cross Section：

193.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

6.1

safety instructions：

Precautionary statement(s)：

P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311

Hazard Statements：

H302-H317-H334

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

MeSH Entry Terms：

T-Gen

Trimethobenzamide hydrochloride Use and Manufacturing

Uses

antiemetic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:424.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:424.1764997
Monoisotopic Mass:424.1764997
Topological Polar Surface Area:69.3
Heavy Atom Count:29
Complexity:440
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Latest News on Trimethobenzamide hydrochloride

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Guide of Trimethobenzamide hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Latest News
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Trimethobenzamide hydrochloride

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