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Bethanechol chloride

Bethanechol chloride structure

CAS No:
590-63-6
Formula:
C7H17N2O2.Cl
Chemical Name:
Bethanechol chloride
Synonyms:
1-Propanaminium,2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-,chloride (1:1);(2-Hydroxypropyl)trimethylammonium chloride carbamate;Ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate;1-Propanaminium,2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-,chloride;Bethanechol chloride;Carbamylmethylcholine chloride;Mechothane;β-Methylcholine chloride urethan;Urecholine;Urecholine chloride;Mechotane;Myocholine;Mictone;Myotonine chloride;Uro-Carb;β-Methyl carbachol chloride;Trimethyl(2-carbamoyloxypropyl)ammonium chloride;Mecothane;Besacholine;(±)-Bethanechol;Myotonachol;NSC 30783;1-(Trimethylazaniumyl)propan-2-yl carbamate chloride;21293-39-0
Categories:
Biochemical Engineering > Inhibitors

Description

Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.Target: mAChRBethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. Oral bethanechol significantly improves contraction pressures and bolus transit in the smooth muscle port

Bethanechol chloride is the chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. It has a role as a muscarinic agonist. It is a carbamate ester, a quaternary ammonium salt and a chloride salt. It contains a bethanechol.|Bethanechol Chloride is a synthetic quaternary ammonium base derivative, parasympathomimetic Bethanechol is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Generally used to increase smooth muscle tone, Bethanechol is used to treat reflux esophagitis and to initiate urination after surgery, in urinary infections, or for enlarged prostate. It may cause hypotension, cardiac rate changes, and bronchial spasms. (NCI04)|A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.

Bethanechol chloride Basic Attributes

Molecular Weight：

196.67500

Exact Mass：

196.09800

EC Number：

209-686-8

NSC Number：

755913|30783

DSSTox ID：

DTXSID2022676

NCI Thesaurus Code：

C28866

HScode：

2924199090

Characteristics

PSA：

52.32000

Melting Point：

218-219 °C (decomp)

Water Solubility：

H2O: 1.7 g/mL stable for several days at 4°C.

Storage Conditions：

2-8ºC

Collision Cross Section：

133 Å² [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22

safety instructions：

S36

RTECS Number：

BR5425000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate. (See all compounds classified as Muscarinic Agonists.)|Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)

MeSH Entry Terms：

Bethanechol

Bethanechol chloride Use and Manufacturing

Uses

1. Cholinergic
2. A selective muscarinic receptor stimulant, used to treat cerebral palsy.

Manufacturing Info：

1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (1:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:196.67
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:196.0978555
Monoisotopic Mass:196.0978555
Topological Polar Surface Area:52.3
Heavy Atom Count:12
Complexity:140
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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