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Gallamine

Gallamine structure

CAS No:
153-76-4
Formula:
C24H45N3O3
Chemical Name:
Gallamine
Synonyms:
Ethanamine,2,2′,2′′-[1,2,3-benzenetriyltris(oxy)]tris[N,N-diethyl-;Triethylamine,2,2′′′,2′′′′′′-(v-phenenyltrioxy)tris-;2,2′,2′′-[1,2,3-Benzenetriyltris(oxy)]tris[N,N-diethylethanamine];Gallamine
Categories:
Organic Chemistry > Amides

Description

ChEBI: A tertiary amine non-depolarising muscle relaxant whose structure comprises a core benzene molecule substituted at each of C-1, C-2 and C-3 by an N,N-diethyl-2-(ethylamino)ethoxy group.

Gallamine is a tertiary amine non-depolarising muscle relaxant whose structure comprises a core benzene molecule substituted at each of C-1, C-2 and C-3 by an N,N-diethyl-2-(ethylamino)ethoxy group. It has a role as a muscle relaxant, a cholinergic antagonist and a drug allergen.|A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)

Gallamine Basic Attributes

Molecular Weight：

423.6324

Exact Mass：

423.63

EC Number：

205-816-2

UNII：

1146X1WTNM

DSSTox ID：

DTXSID60165184

ATC Code：

M - Musculo-skeletal system

Characteristics

PSA：

37.4

XLogP3：

4.1

Boiling Point：

206 °C @ Press: 1 Torr

Drug Information

MeSH：

Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)|Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)

MeSH Entry Terms：

Flaxedil

Gallamine Use and Manufacturing

Neuromuscular blocking agent.

Computed Properties

Molecular Weight:423.6
XLogP3:4.1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:18
Exact Mass:423.34609231
Monoisotopic Mass:423.34609231
Topological Polar Surface Area:37.4
Heavy Atom Count:30
Complexity:362
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes