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Buclizine hydrochloride

Buclizine hydrochloride structure

CAS No:
129-74-8
Formula:
C28H33ClN2.2ClH
Chemical Name:
Buclizine hydrochloride
Synonyms:
Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,hydrochloride (1:2);Piperazine,1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-,dihydrochloride;Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,dihydrochloride;UCB 4445;Buclodin;1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride;1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine hydrochloride;1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride;Histabutyzine hydrochloride;Softran;Vibazine Hydrochloride;Buclizine hydrochloride;Buclizine dihydrochloride;Longifene;Aphilan R;Buclina;Vibazine;Bucladin S;NSC 25141;1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
Categories:
Biochemical Engineering > Inhibitors

Description

Buclizine dihydrochloride is a hydrochloride salt that is obtained by reaction of buclizine with 2 equivalents of hydrogen chloride. It has a role as a central nervous system depressant, a local anaesthetic, a histamine antagonist, a cholinergic antagonist and an antiemetic. It contains a buclizine(2+).

Buclizine hydrochloride Basic Attributes

Molecular Weight：

505.95

Exact Mass：

504.186584

EC Number：

204-962-4

UNII：

EOP5593FPH|V4OCE982YU

DSSTox ID：

DTXSID5045091

Characteristics

PSA：

6.48000

XLogP3：

8.02450

Appearance：

Off-White Powder

Melting Point：

230-240 °C

Boiling Point：

520.1ºC at 760 mmHg

Flash Point：

268.3ºC

Storage Conditions：

-20°C Freezer

Vapor Pressure：

6.44E-11mmHg at 25°C

Toxicity：

Oral-Mouse LD50: 2100 mg/kg; Abdominal cavity-mouse LD50: 430 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxides and chloride fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

MeSH Entry Terms：

1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)piperazine

Buclizine hydrochloride Use and Manufacturing

Uses

Used as anantiemetic

Manufacturing Info：

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:505.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:504.186582
Monoisotopic Mass:504.186582
Topological Polar Surface Area:6.5
Heavy Atom Count:33
Complexity:514
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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CAS No.: 129-74-8

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