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3-Amino-1-propanol

3-Amino-1-propanol structure

CAS No:
156-87-6
Formula:
C3H9NO
Chemical Name:
3-Amino-1-propanol
Synonyms:
1-Propanol,3-amino-;3-Amino-1-propanol;β-Alaninol;3-Aminopropanol;3-Hydroxypropylamine;Propanolamine;3-Aminopropyl alcohol;γ-Aminopropanol;1-Amino-3-propanol;3-Propanolamine;1-Amino-3-hydroxypropane;3-Hydroxy-1-propylamine;γ-Hydroxy-1-propylamine;1,3-Propanolamine;3-Hydroxy-1-aminopropane;NSC 7766;N-(3-Hydroxypropyl)amine;3-Hydroxypropan-1-amine;3-Aminopropan-1-ol
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

clear colourless to very slightly yellow liquidColorless to pale yellow liquid with a fishy odor. Less dense than water. Melting point 12.4°C (54°F). Moderately toxic by ingestion.

N-propanolamine is a colorless to pale yellow liquid with a fishy odor. Less dense than water. Melting point 12.4°C (54°F). Moderately toxic by ingestion.

N-propanolamine is a colorless to pale yellow liquid with a fishy odor. Less dense than water. Melting point 12.4°C (54°F). Moderately toxic by ingestion.|3-aminopropan-1-ol is a member of the class of propanolamines that is propane with a hydroxy substituent at C-1 and an amino substituent at C-2, making it both a primary amine and a primary alcohol. It is a primary alcohol, a primary amine and a propanolamine.

3-Amino-1-propanol Basic Attributes

Molecular Weight：

75.11

Exact Mass：

75.11

BRN：

741855

EC Number：

205-864-4

UNII：

YMA7C44XGY

NSC Number：

7766

UN Number：

2735

DSSTox ID：

DTXSID0059746

Color/Form：

COLORLESS LIQUID

HScode：

29221980

Characteristics

PSA：

46.2

XLogP3：

-1.1

Appearance：

Clear colorless to very slightly yellow Liquid

Density：

0.9824 g/cm³ @ Temp: 26 °C

Melting Point：

12.4 °C

Boiling Point：

187-188 °C @ Press: 756 Torr

Flash Point：

175 °F

Refractive Index：

n 20/D 1.4598(lit.)

Water Solubility：

Micible with water.

Storage Conditions：

Store below +30°C.

Vapor Pressure：

2.1 mm Hg ( 20 °C)

Vapor Density：

2.59 (vs air)

Toxicity：

LD50 orally in Rabbit: 1300 mg/kg LD50 dermal Rat > 2000 mg/kg

Explosive limit：

2.5-10.6%(V)

Air and Water Reactions：

Water soluble.

Reactive Group：

Alcohols and Polyols

Reactivity Profile：

N-PROPANOLAMINE neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Reacts with strong reducing agents, such as hydrides to generate flammable gaseous hydrogen.

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 2735 8/PG 2

wgk germany：

hazard class code：

22-34-20/21/22

safety instructions：

26-36/37/39-45

RTECS Number：

UA5600000

Marks：

C,Xn

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H302-H314

Fire Hazards：

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire. Behavior in Fire: May produce toxic oxides of nitrogen. (USCG, 1999)

GHS Classification：

|Danger|H302 (92.27%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 233 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P264, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P363, P370+P378, P403+P235, P405, and P501

Fire Fighting：

Fire Extinguishing Agents: Small fires: Dry chemical, CO 2 , water spray or alcohol foam. Large fires: Water spray, fog or alcohol foam. (USCG, 1999)

Isolation and Evacuation：

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Nonfire Spill Response：

Neutralizing Agents for Acids and Caustics: Cover spilled material with sodium bisulfate. Flush with water. (USCG, 1999)

Personal Protective Equipment：

Wear butyl rubber gloves and face shield or all-purpose canister respirator for spills. Wear self-contained breathing apparatus and full protective clothing for fires. (USCG, 1999)

Drug Information

Health Hazards：

If inhaled may be harmful. Contact may cause burns to skin and eyes. (Organic base.) (USCG, 1999)

First Aid：

INHALATION: Move victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. SKIN AND EYES: Immediately flush skin or eyes with running water for at least 15 minutes; hold eyelids open if necessary. Remove and isolate contaminated clothing and shoes. Maintain normal body temperature. (USCG, 1999)

Human Toxicity Excerpts：

MODERATELY TOXIC BY INGESTION; MODERATE IRRITANT TO TISSUE.

MeSH Entry Terms：

3-amino-1-propanol

3-Amino-1-propanol Use and Manufacturing

Methods of Manufacturing

Derived from the catalytic hydrogenation of β-hydroxypropionitrile. Add β-hydroxypropionitrile, Raney nickel, ethanol, ammonia to the autoclave, pass hydrogen to 2.94MPa, maintain the hydrogen pressure at 100-120℃, and continue to keep the heat for 2h after not absorbing hydrogen. After the reaction was completed, the temperature was lowered, the Raney nickel was recovered by filtration, the filtrate was distilled under reduced pressure, and the 90-92°C/2.0kPa fraction was collected. The content was above 95%, and the yield was close to 70%.

Uses

Organic intermediate.

Drumming

Production

(1977) No Data|(1980) PROBABLY GREATER THAN 2.27X10+6 GRAMS

Formulations：

GRADE: 99% PURE.

Manufacturing Info：

All other basic organic chemical manufacturing|1-Propanol, 3-amino-: ACTIVE

Computed Properties

Molecular Weight:75.11
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:75.068413911
Monoisotopic Mass:75.068413911
Topological Polar Surface Area:46.2
Heavy Atom Count:5
Complexity:16.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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