2-Phenyl-4-quinolinecarboxylic acid

249.26

249.26

192803

205-067-1

39Y533Z02M

758887|70178|2617

DTXSID0040705

NEEDLES FROM METHANOL OR DILUTED ALCOHOL|WHITE OR YELLOWISH CRYSTALS OR POWDER|SMALL, WHITE, NEEDLE-LIKE CRYSTALS

M - Musculo-skeletal system

29334990

50.2

3.99

1.1426 (rough estimate)

218 °C

392.37°C (rough estimate)

230.1±25.4 °C

1.5300 (estimate)

Insoluble in water;alcohol: soluble 1g in 120ml(lit.)

Store below +30°C.

3.84E-09mmHg at 25°C

LD50 oral in dog: 1250mg/kg

ODORLESS

SLIGHTLY BITTER TASTE

154.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

OPTIC SIGN: +; ELONGATION: +; AXIAL ANGLE: 2V= 45 DEG /ORTHORHOMBIC SYSTEM/|OPTIC SIGN: -; AXIAL ANGLE: LARGE /TRICLINIC SYSTEM/|YELLOW CRYSTALLINE POWDER; SLIGHTLY BITTER, ASTRINGENT TASTE; MP: 223 °C; PRACTICALLY INSOL IN WATER; SLIGHTLY SOL IN ALCOHOL; SOL IN CHLOROFORM, ETHER /HYDROCHLORIDE/

III

6.1(b)

3249

3

22

36/37/39-26

GD4025000

Xn

STABLE TO AIR, BUT TURNS YELLOW UNDER THE INFLUENCE OF LIGHT

P264, P270, P301+P312, P330, P501

H302

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 45 companies from 2 notifications to the ECHA C&L Inventory.

IN DOGS, CINCHOPHEN HAD NO EFFECT ON IOPANOIC ACID EXCRETIO BUT INCR BOTH BILIARY & URINARY EXCRETION OF IOPHENOXIC ACID.

Anti-Inflammatory Agents, Non-Steroidal|/IT WAS USED AS/ ANALGESIC IN ACUTE GOUT, ACTING MORE PROMPTLY THAN COLCHICUM & WITHOUT UNDESIRABLE SIDE EFFECTS. ... DOSE: ORAL, 0.5 G.|ONCE USED AS URICOSURIC, ANALGESIC & ANTI-INFLAMMATORY AGENT

THE OCCURRENCE OF JAUNDICE WITH CINCHOPHEN & ITS VARIOUS DERIV WAS OBSERVED WITH SUCH FREQUENCY & HERALDED SUCH SEVERE DEGENERATIVE & NECROTIZING CHANGES IN LIVER THAT THESE DRUGS HAVE BEEN LARGELE ABANDONED.|QUINIDINE, ADMIN PARENTERALLY SHORTLY AFTER OR SIMULTANEOUSLY WITH TUBOCURARINE, MAY ENHANCE OR CAUSE RECURRENT NEUROMUSCULAR EFFECTS OF TUBOCURARINE... ALTHOUGH NO DRUG INTERACTION HAS BEEN DOCUMENTED, OTHER CINCHONA ALKALOIDS (EG CINCHOPHEN & QUININE) MAY ALSO INTERACT WITH TUBOCURARINE.|CLINICAL & EXPTL STUDIES SHOW THAT ANTIARRHYTHMIC & CARDIODEPRESSANT EFFECTS OF QUINIDINE MAY BE ENHANCED BY ADMIN OF RESERPINE. ... CINCHOPHEN & QUININE ARE AGENTS RELATED TO QUINIDINE.|THE OTHER CINCHONA ALKALOIDS, CINCHOPHEN & QUININE, APPARENTLY EXERT DIRECT HYPOPROTHROMBINEMIC EFFECT BY DEPRESSING THE HEPATIC ENZYME SYSTEM THAT SYNTHESIZES VITAMIN K-DEPENDENT FACTORS...& COULD INTERACT WITH WARFARIN ALSO.

3. 3= MODERATELY TOXIC; PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).

2% 2-O-OXYPHENYLQUINOLINE-4-CARBOXYLIC ACID WAS EXCRETED IN URINE FROM HUMANS AFTER DOSAGE WITH CINCHOPHEN. /FROM TABLE/|YIELDS 8-HYDROXY-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID & 2-(P-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID IN DOG: HARTIALA, K, TERHO, T & HAKKINEN, I; BIOCHEM PHARMAC, 16, 843 (1967). /FROM TABLE/

IN BLOOD OF HUMANS HALF LIFE AFTER DOSAGE OF CINCHOPHEN WAS 4-4.5 HR.

aciphenochinolium

IN COMBINATIONS WITH SODIUM SALICYLATE AS ATOPHANYL; ARTHROSAN; CINCOSAL. HYDROCHLORIDE, C16H12CLNO2, CHLOROXYL. ... LITHIUM SALT OCTAHYDRATE, C16H10LINO2, EKTOPHANOL.

TITRIMETRIC DETERMINATION OF CINCHOPHEN IN PRESENCE OF SALICYLATES & SODIUM BICARBONATE.|UV ABSORPTION DATA, INCL MAX WAVELENGTH & OTHER SOLVENTS FOR MORE THAN 150 DRUGS ARE GIVEN.|STRONGER BASES SUCH AS ACIPHENOQUINOLINE WERE DETERMINED IN PHARMACEUTICALS, SEPARATED OR IN PRESENCE OF ONE ANOTHER, BY TITRATION.

Pharmaceuticals