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Chloroquine sulfate

Chloroquine sulfate structure

CAS No:
132-73-0
Formula:
C18H26ClN3.H2O4S
Chemical Name:
Chloroquine sulfate
Synonyms:
1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-,sulfate (1:1);Quinoline,7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-,sulfate (1:1);Melubrin;7-Chloro-4-(4′-diethylamino-1-methylbutylamino)quinoline sulfate;Chloroquine sulfate;Chlorquine sulfate;Nivaquine;Ciplaquin;Lariago;NSC 292296;Resochine;Melubrine
Categories:
Chemical Reagents > Organic Reagents

Description

The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.

Chloroquine sulfate Basic Attributes

Molecular Weight：

417.951

Exact Mass：

417.148895

EC Number：

205-077-6

NSC Number：

292296

Characteristics

PSA：

111.14000

XLogP3：

5.31160

Density：

0.773 g/mL at 25 °C(lit.)

Boiling Point：

84-86 °C35 mm Hg(lit.)

Flash Point：

99 °F

Refractive Index：

n20/D 1.434(lit.)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

Drug Information

MeSH：

Drugs that are used to treat RHEUMATOID ARTHRITIS. (See all compounds classified as Antirheumatic Agents.)|Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal. (See all compounds classified as Amebicides.)

MeSH Entry Terms：

Aralen

Computed Properties

Molecular Weight:418.0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:417.1489053
Monoisotopic Mass:417.1489053
Topological Polar Surface Area:111
Heavy Atom Count:27
Complexity:390
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes