 Home > Encyclopedia > Sodium p-aminosalicylate

Sodium p-aminosalicylate

Sodium p-aminosalicylate structure

CAS No:
133-10-8
Formula:
C7H7NO3.Na
Chemical Name:
Sodium p-aminosalicylate
Synonyms:
Benzoic acid,4-amino-2-hydroxy-,sodium salt (1:1);Salicylic acid,4-amino-,monosodium salt;Benzoic acid,4-amino-2-hydroxy-,monosodium salt;p-Aminosalicylate sodium;p-Aminosalicylic acid sodium salt;Bactylan;Lepasen;Natri-Pas;Nippas;Pamisyl Sodium;Pasalon-Rakeet;PASNa;Pasnal;Passodico;Salvis;Sanipirol;Sodium PAS;Tubersan;4-Aminosalicylic acid sodium salt;Sodium 4-aminosalicylate;Sodium p-aminosalicylate;Pasade;Sodiopas;Sodium 4-amino-2-hydroxybenzoate;Sodium 2-hydroxy-4-aminobenzoate;Monopas;8031-28-5;857363-33-8;1081807-72-8
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Request for Quotation

Description

Aminosalicylate sodium anhydrous is an organic molecular entity.

Sodium p-aminosalicylate Basic Attributes

Molecular Weight：

175.12

Exact Mass：

175.024536

EC Number：

205-091-2

UNII：

T9ZKL3TNQF

DSSTox ID：

DTXSID0046066

ATC Code：

J - Antiinfectives for systemic use

HScode：

2918219000

Characteristics

PSA：

86.4

XLogP3：

-0.08090

Appearance：

white crystalline

Density：

1.491g/cm3

Melting Point：

265-270 °C

Boiling Point：

380.8ºC at 760 mmHg

Flash Point：

184.1ºC

Vapor Pressure：

1.78E-06mmHg at 25°C

Toxicity：

Oral-rat LD50: 8000 mg/kg; Oral-Mouse LD50: 6900 mg/kg

Flammability characteristics：

Flammable; produces toxic sodium oxide and nitrogen oxide gases when burned

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

VO1700000

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; stored separately from alkali

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 11 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

practically nontoxic

Sodium p-aminosalicylate Use and Manufacturing

Uses

It is an anti-tuberculosis drug and is mainly used for the comprehensive treatment of various tuberculosis infections

Manufacturing Info：

Benzoic acid, 4-amino-2-hydroxy-, sodium salt (1:1): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:175.12
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:175.02453734
Monoisotopic Mass:175.02453734
Topological Polar Surface Area:86.4
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has an antibacterial effect only on Mycobacterium tuberculosis. It inhibits the growth and reproduction of Mycobacterium tuberculosis by competitively inhibiting the synthesis of folic acid.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sodium p-aminosalicylate enteric-coated tablets
Ingredients	Sodium p-aminosalicylate. Its chemical name is: 4-amino-2-hydroxybenzoic acid sodium salt dihydrate. Molecular formula: C7H6NNaO32H2O, molecular weight: 211.14.
Indication	1. Para-aminobenzoic acid and this product have antagonistic effects, and the two should not be used together. 2. This product can enhance the effect of anticoagulants (coumarin or indandione derivatives), so the dose of oral anticoagulants should be appropriately adjusted when using para-aminosalicylic acid or after using it. 3. When used in combination with ethionamide, adverse reactions may increase. 4. The combination of probenecid or sulfinpyrazone with aminosalicylic acid can reduce the secretion of the latter from the renal tubules, leading to increased blood drug concentrations, prolonged duration, and toxic reactions. Therefore, when aminosalicylic acid is used in combination with probenecid or sulfinpyrazone or after the combination, the dose of the former should be appropriately adjusted, and the patient should be closely followed up. However, most people do not use probenecid as an auxiliary drug for aminosalicylic acid treatment. 5. Aminosalicylic acid may affect the absorption of rifampicin, resulting in a decrease in the blood concentration of rifampicin. Patients must be informed that they should be at least 6 hours apart when taking the above two drugs. 6-Aminosalicylates and vitamin B12 can affect the absorption of the latter from the gastrointestinal tract when taken together. Therefore, patients taking aminosalicylic acids may have an increased requirement for vitamin B12.
Specifications	0.5g
Manufacturer	HUAZHONG Pharmaceutical Co., Ltd.

Sodium p-aminosalicylate
Manufacturer	Harbin Pharmaceutical Group Sanjing Mingshui Pharmaceutical Co., Ltd.

Sodium p-aminosalicylate enteric-coated tablets
Ingredients	Sodium p-aminosalicylate. Its chemical name is: 4-amino-2-hydroxybenzoic acid sodium salt dihydrate. Molecular formula: C7H6NNaO32H2O, molecular weight: 211.14.
Indication	1. Para-aminobenzoic acid and this product have antagonistic effects, and the two should not be used together. 2. This product can enhance the effect of anticoagulants (coumarin or indandione derivatives), so the dose of oral anticoagulants should be appropriately adjusted when using para-aminosalicylic acid or after using it. 3. When used in combination with ethionamide, adverse reactions may increase. 4. The combination of probenecid or sulfinpyrazone with aminosalicylic acid can reduce the secretion of the latter from the renal tubules, leading to increased blood drug concentrations, prolonged duration, and toxic reactions. Therefore, when aminosalicylic acid is used in combination with probenecid or sulfinpyrazone or after the combination, the dose of the former should be appropriately adjusted, and the patient should be closely followed up. However, most people do not use probenecid as an auxiliary drug for aminosalicylic acid treatment. 5. Aminosalicylic acid may affect the absorption of rifampicin, resulting in a decrease in the blood concentration of rifampicin. Patients must be informed that they should be at least 6 hours apart when taking the above two drugs. 6-Aminosalicylates and vitamin B12 can affect the absorption of the latter from the gastrointestinal tract when taken together. Therefore, patients taking aminosalicylic acids may have an increased requirement for vitamin B12.
Specifications	0.5g
Manufacturer	Ningxia QIYUAN Chinese MEDICINE Co., Ltd.

See More Related Drugs

Registered Holders

Kaifeng Pharmaceutical (GROUP) Co., Ltd.

China
Active
China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active
Harbin Pharmaceutical Group Sanjing Mingshui Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Sodium p-aminosalicylate

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity Sodium 4-aminosalicylate CAS 133-10-8

CAS No.: 133-10-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

Sodium 4-aminosalicylate

CAS No.: 133-10-8

Grade: industrial Grade

Content: 98%

Inquiry