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Sodium ethoxide

Sodium ethoxide structure

CAS No:
141-52-6
Formula:
C2H6O.Na
Chemical Name:
Sodium ethoxide
Synonyms:
Ethanol,sodium salt (1:1);Ethyl alcohol,sodium salt;Ethanol,sodium salt;Caustic alcohol;Sodium ethoxide;Sodium ethylate;Sodium ethanolate;Ethoxysodium;Sodium ethoxylate;24448-24-6;1628390-26-0
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

White powder, sometimes having brownish tinge; readily hydrolyzes to alcohol and sodium hydroxide. ChEBI: An organic monosodium salt that has ethoxide as the counterion.White or yellowish powder; hygroscopic; darkens and decomposes on exposure to air; decomposes in water forming sodium hydroxide and ethanol; dissolves in absolute ethanol.

Liquid|WHITE-TO-YELLOW POWDER.

Sodium ethoxide is an organic monosodium salt that has ethoxide as the counterion. It has a role as a nucleophilic reagent. It contains an ethoxide.

Sodium ethoxide Basic Attributes

Molecular Weight：

68.05

Exact Mass：

68.023811

EC Number：

205-487-5

UNII：

1I9504387J

ICSC Number：

0674

DSSTox ID：

DTXSID3027089

Color/Form：

WHITE OR YELLOWISH POWDER|WHITE POWDER SOMETIMES HAVING BROWNISH TINGE

HScode：

29051900

Characteristics

PSA：

23.06000

XLogP3：

0.43680

Appearance：

Liquid

Density：

0.868 g/cm³

Melting Point：

260 °C

Boiling Point：

91°C

Flash Point：

48 °F

Refractive Index：

n 20/D 1.386

Water Solubility：

soluble in ethanol and methanol.

Storage Conditions：

Store at R.T.

Vapor Pressure：

<0.1 mm Hg ( 20 °C)

Vapor Density：

1.6 (vs air)

Toxicity：

LD50 orally in Rabbit: 598 mg/kg

Experimental Properties：

DECOMP BY WATER INTO SODIUM HYDROXIDE & ALC; HYGROSCOPIC

Safety Information

Packing level：

Hazard category：

4.2

Transport codes：

UN 3274 3/PG 2

wgk germany：

hazard class code：

R11;R14;R34

safety instructions：

8-16-26-43-45-36/37/39-36-61

Marks：

F,C,Xi,N

Storage features：

Fireproof. Dry. Well closed.

Stability/Shelf Life：

Reacts violently with acids, water. Incompatible with chlorinated solvents, moisture. Absorbs carbon dioxide from the air. Highly flammable.

Precautionary statement(s)：

P210-P235 + P410-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

Hazard Statements：

H228-H251-H314

Fire Hazards：

Highly flammable. Risk of fire and explosion on contact with water.

GHS Classification：

|Danger|H228 (35.67%): Flammable solid [Danger Flammable solids]|P210, P235+P410, P240, P241, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P370+P378, P405, P407, P413, P420, and P501|Aggregated GHS information provided by 443 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H251: Self-heating; may catch fire [Danger Self-heating substances and mixtures]|P235+P410, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, P407, P413, P420, and P501|Not Classified

Fire Fighting：

NO water. Use dry powder, dry sand. NO hydrous agents. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

Spillage Disposal：

Personal protection: chemical protection suit. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Remove all ignition sources. Sweep spilled substance into covered air-tight, dry containers.

Safe Storage：

Fireproof. Dry. Well closed.

Inhalation Risk：

A harmful concentration of airborne particles can be reached quickly when dispersed.

Effects of Short Term Exposure：

Corrosive.

Fire Prevention：

NO open flames, NO sparks and NO smoking.

Exposure Prevention：

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Inhalation Prevention：

Use closed system or ventilation.

Skin Prevention：

Protective gloves. Protective clothing.

Eye Prevention：

Wear safety goggles or eye protection in combination with breathing protection if powder.

Drug Information

First Aid：

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

MeSH Entry Terms：

sodium ethoxide

Symptoms：

Burning sensation. Cough. Laboured breathing. Shortness of breath. Sore throat.

Redness. Pain. Blisters. Skin burns.

Redness. Pain. Severe deep burns.

Sodium ethoxide Use and Manufacturing

Methods of Manufacturing

BY CAREFULLY ADDING SMALL AMT OF SODIUM TO ABSOLUTE ALC KEPT @ TEMP OF 10 °C, HEATING CAREFULLY TO 37.7 °C, AGAIN CAREFULLY ADDING SODIUM, COOLING TO 10 °C, & ADDING SAME QUANTITY OF ABSOLUTE ALC AS WAS USED ORIGINALLY.

Uses

Sodium ethoxide is used in organic synthesis for condensation reactions. It also is a catalyst in many organic reactions.

Intermediates

Fuels and related products

Production

(1986) No Data

Manufacturing Info：

Agriculture, forestry, fishing and hunting|Ethanol, sodium salt (1:1): ACTIVE|AN ADDITIVE IN SOLID HAIR STRAIGHTENING COMPD.

Analytic Methods：

SODIUM ETHYLATE DETERMINED BY TITRATION.

Computed Properties

Molecular Weight:68.05
Hydrogen Bond Acceptor Count:1
Exact Mass:68.02380906
Monoisotopic Mass:68.02380906
Topological Polar Surface Area:23.1
Heavy Atom Count:4
Complexity:6
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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