Endosulfan sulfate

422.92

422.92

200-659-6

2761

DTXSID3037541

60.98000

4.30

Clear colorless Liquid

1.9±0.1 g/cm3

181-182 °C

480.7±45.0 °C at 760 mmHg

-26 °C

1.638

1.14e-06 M

APPROX 4°C

2.80e-07 mmHg

Endosulfan sulfate did not degrade when thin films /containing the compound/ were treated with ... radiation at 254 nm.

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

ENDOSULFAN SULFATE is an organochlorine and cycloalkene. It is also a sulfate ester. Corrosive to iron. It can be hydrolyzed by aqueous alkali or acid, generating sulfur dioxide. Incompatible with strong oxidizing and reducing agents. Also incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. As an ester, it will hydrolyze to form sulfur dioxide and diol; reaction is more rapid under basic conditions.

II

6.1(a)

2761

28-50/53-67-65-62-51/53-48/20-38-11-39/23/24/25-23/24/25

22-24/25-45-60-61-62-36/37-16-7-33-29-9

RB9150000

T+,N,Xn,F,T

P264-P273-P301 + P310

H300-H400

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Potential candidate for rotary kiln incineration with a temperature range of 820-1600 °C with a residence time for liquids and gases: seconds; Solids: hours. /Endosulfan/

USEPA; Ambient Water Quality Criteria Doc: Endosulfan (1980) EPA 440/5-80-046|Chopra NM; J Agric Food Chem 25 (1): 32-6 (1977). Metabolism of Endosulfan I, Endosulfan II, and Endosulfan Sulfate in Tobacco Leaf.|WHO; Environ Health Criteria: Endosulfan (1984)|Nat'l Research Council Canada; Endosulfan (1975) NRCC No. 14098|For more Special Reports (Complete) data for ENDOSULFAN SULFATE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 8 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

To extinguish a fire involving this chemical you may use a dry chemical, carbon dioxide, foam or halon extinguisher; a water spray may also be used. (NTP, 1992)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light, and store it in a freezer. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). RECOMMENDED GLOVE MATERIALS: Permeation data indicate that butyl rubber gloves may provide protection to contact with this compound. Butyl rubber over latex gloves is recommended. However, if this chemical makes direct contact with your gloves, or if a tear, hole or puncture develops, remove them at once. (NTP, 1992)

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Endosulfan sulfate was detected in 1.6% of 850 United States industrial and municipal effluent samples at a median concn of <0.020 ppb, according to the USEPA STORET database(1). Endosulfan sulfate was not detected in the National US Urban Runoff Program, which sampled 15 cities since the inception of the Clean Water Act of 1972 to July 31, 1982(2).|Farm ditches flowing into three rivers important to fisheries in the Lower Fraser Valley of British Columbia, Canada, were sampled periodically at seven locations from July to December 1991 to determine endosulfan and its residues in ditch water and sediment(1). Endosulfan sulfate was found in soils, sediment, and water at mean concns of 1,015 ug/l, 218 ug/l, and 0.30 ug/l, respectively(1). Six sampling events (totaling 168 samples) of New York City municipal wastewaters from 1989-1993, were performed to determine the frequency of organic priority pollutants(2). Endosulfan sulfate was detected only once in 1992 at a concn ranging from 0.013-0.052 ug/l in influent water and at 0.26 ug/l in effluent(2). Influent and effluent water samples were collected from the Cedar Creek Wastewater Reclamation Plant located in Nassau County, NY in April, May and June, 1981(3). Endosulfan sulfate was detected in influent and effluent at 189 and 187 ng/l(3). This represents only a 1% removal by the wastewater reclamation plant(3).

Soil samples from five metropolitan areas including Baltimore, Md; Gadsen, Al; Hartford, CT; Macon, Ga; and New Port News, VA were analyzed for elemental arsenic, organochlorine pesticides, and polychlorinated biphenyls (PCBs). ... All areas exhibited heavy soil concentrations of organochlorine pesticides including: ... endosulfan sulfate. ... Within the metropolitan areas, samples from the urban, or core city, locations ... had higher pesticide concentrations than did samples from surburban locations. ... Pesticide residue concentrations were ... higher in soils of metropolitan areas than in nearby agricultural soils.|... Studies were conducted on the occurrence and magnitude of ... endosulfan sulfate residues in soil samples obtained from commercially treated fields in New Jersey, Wisconsin, Florida, Minnesota, and North Dakota. Various crops were treated one to five years with foliar applications (0.56-1.12 kg/ha). Intervals from the last application to the data sampling ranged from 100 days to approximately five years. ... Endosulfan sulfate was detected at ... 0.07-1.06 mg/kg (soil) in 10 of 14 soil monitoring samples.|/During 1972 ... a pond near/ Simcoe, Ontario, following aerial application of endosulfan to local tobacco fields ... /the sediments/ contained 0.9 ug/kg (dry weight) of a-endosulfan, 1.0 ug/kg (dry weight) of b-endosulfan, and 1.1 ug/kg (dry weight) of endosulfan sulfate at the east end of the pond. The west end of the pond contained 1.2 ug/kg (dry weight) of endosulfan sulfate.|SOIL: In 1989, a study was conducted to determine the identities and concns of organochlorine pesticides in three soil types from 12 farms located in the Fraser Valley of British Columbia, Canada(1). Endosulfan sulfate was detected on all 12 farms in loamy sand, silt loam and muck soils at a mean concn of 38 ppb, 251 ppb, 3693 ppb, respectively(1). Endosulfan sulfate was detected in Canadian agricultural soils ranging from not detected-7.9 ug/kg dy weight(2). Endosulfan sulfate was detected in 1 out of 156 soil samples from Baltimore, MD in 1971 at 0.17 ppm avg dry wt of all samples(4). It was also detected in 1 out of 43 samples in Macon, GA at 2.3 ppm avg dry wt of all samples. Endosulfan sulfate was not detected in all 55 soil samples from Gadsden, AL, 48 samples from Hartford, CT or in 78 samples from Newport News, VA(4). SEDIMENT: Endosulfan was not detected in over 290 sediment samples analyzed in the US EPA STORET database(3).

RURAL/REMOTE: Air samples collected from a Spanish National Park in the Pyrenees Mountains and in the surroundings of an industrial waste dump were analyzed for organochlorine compounds(1). Endosulfan sulfate was not detected in any air samples analyzed (detection limit = 1 pg/cu m)(1).

Pyrolysis studies on tobacco indicate that the alpha and beta-isomers, the sulfate derivative, and a variety of of other products are present in contaminated tobacco smoke.|Residues /found in tobacco/ ... consist primarily of endosulfan sulfate.|ENDOSULFAN RESIDUES WERE NONDETECTABLE (LESS THAN 0.01 PPM) IN THE 1970 & 1971 CIGARETTE TOBACCO, BUT IN 1972 THEY AVERAGED 0.4 PPM WITH 0.3 PPM AS ENDOSULFAN SULFATE, 0.1 PPM AS ENDOSULFAN II, & ONLY TRACE AMOUNTS OF ENDOSULFAN I.

Endosulfan sulfate is expected to occur in the environment as the oxidative degradation product(1-3) and as the biodegradative product(4,5) of the pesticide endosulfan. It is also formed in plants and mammals by metabolism of endosulfan(6). Endosulfan bioconcentrated in striped mullet was rapidly metabolized to endosulfan sulfate(7).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3.2X10+4(SRC), determined from a structure estimation method(2), indicates that endosulfan sulfate is expected to be immobile in soil(SRC). Volatilization of endosulfan sulfate from moist soil surfaces is not pected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-11 atm-cu m/mole(SRC), from its vapor pressure of 1.0X10-11 mm Hg(3) and water solubility of 0.48 mg/l(4). Endosulfan sulfate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Endosulfan sulfate is expected to biodegrade slowly in soils based on its degradation in four soils, a Pliocene sand, an organic-rich orchard soil, an agricultural soil and soil from a volcanic area, with a half-life in each of 164, 157, 150, and 134 days, respectively(5). The degradation of endosulfan sulfate was due to a combination of both abiotic processes and biodegradation(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3.2X10+4(SRC), determined from an estimation method(2), indicates that endosulfan sulfate is expected to adsorb to sediment and suspended solids in water(SRC). Volatilization from water surfaces will not occur(3) based upon an estimated Henry's Law constant of 1.2X10-11 atm-cu m/mole, from its vapor pressure of 1.0X10-11 mm Hg(4) and water solubility of 0.48 mg/l(5). Based on endosulfan sulfate's biodegradation half-life in various soils ranging from 134-164 days(6), biodegradation in aquatic systems is expected to be slow. Supporting this is a biodegradation study in which a lack of degradation of endosulfan sulfate occurred in a standard screening tests for a 7 day static incubation period with settled domestic wastewater as inoculum, followed by 3 weekly subcultures(7). Based on a microcosm experiment in which 22% of initial concn of endosulfan sulfate in water (pH not specified) degraded after 33 days, chemical hydrolysis may be important(8). This degradation rate would correspond to a minimum hydrolysis half-life of 178 days(8). According to a classification scheme(9), an estimated BCF of 130(SRC), from its log Kow of 3.66(10) and a regression-derived equation(11), suggests the potential for bioconcentration in aquatic organisms is high.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), endosulfan sulfate, which has a vapor pressure of 1.0X10-11 mm Hg at 25 °C(2), is expected to exist in the particulate phases in the ambient atmosphere. Particulate-phase endosulfan sulfate may be removed from the air by wet and dry deposition(SRC).

Endosulfan sulfate ... a major degradation product found on plant surfaces. /Data indicates that/ thermolysis is the principal mechanism involved in the conversion of endosulfan isomers to the sulfate, but sunlight (photolysis) may play a role in the reaction /possibly/ the initiation.|Based on a microcosm experiment in which 22% of the initial concn of endosulfan sulfate in water (pH not specified) degraded after 33 days, hydrolysis may be an important process(1). This degradation rate would correspond to a minimum hydrolysis half-life of 178 days(1). For comparison, the calculated hydrolysis half-lives for alpha- and beta-endosulfan are 35.4 and 37.5 days at pH 7.0 and 150.6 and 187.3 days at pH 5.5(2). Data concerning the photolysis of endosulfan sulfate is conflicting. One referece states that endosulfan sulfate is susceptible to photolysis(3) while another states that thin films of endosulfan sulfate on glass plates were stable when irradiated with UV light (>300nm)(1). The disappearance of endosulfan sulfate was studied after application to lentil plants in the sub-tropic region of Ludhiana, India(4). Twelve days after the application of endosulfan sulfate, only 4% still remained on the crops. The disappearance of endosulfan sulfate was due to both abiotic processes and biodegradation(4). Endosulfan sulfate is the major oxidation product of endosulfan(5). The half-life of endosulfan sulfate in a sealed sterile aerobic aqueous solution is 184 days and 96 days in an unsealed container(5).|AFTER SPRAYING ENDOSULFAN (3:2 MIXTURE OF I & II ISOMERS) ON FOLIAGE, ENDOSULFAN I DECR TO 30% OF INITIAL DEPOSIT AFTER 1 WK & TO 2% AFTER 3 WK. ENDOSULFAN II DECREASED TO 47% AFTER 1 WK & TO 2% AFTER 7 WK. ALL LEAF EXTRACTS CONTAINED A MORE PERSISTENT CMPD IDENTIFIED AS ENDOSULFAN SULFATE. 75% OF RESIDUE WAS IN THE FORM OF SULFATE AFTER 3 WK & 90% AFTER 7-11 WK.|Aquatic Fate: Terminal residues found in aquatic ecosystems include endosulfan sulfate. ... Endosulfan sulfate is the major product expected under aerobic conditions in slightly acidic waters. Oxidation is slow ... under anaerobic conditions.|For more Environmental Abiotic Degradation (Complete) data for ENDOSULFAN SULFATE (6 total), please visit the HSDB record page.

... Endosulfan sulfate /is more/ soluble in water and conversely less soluble in lipids than the organo chlorine pesticides which ... usually associate with extensive accumulation through the food chain. /Endosulfan sulfate/ is more readily degraded by living organisms ... based on these factors alone ... it would not tend to accumulate to as great an extent as some other organochlorines in the lipid rich "pools" found within aquatic ecosystems.|An estimated BCF of 130 was calculated for endosulfan sulfate(SRC), using a log Kow of 3.66(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high. Endosulfan accumulated 600X in the Pelecypod, Mytilus edulis after 50 hr(4). From these results, bioconcentration of alpha-endosulfan, beta-endosulfan and the metabolite endosulfan sulfate may be somewhat significant in aqueous species(SRC).

... Endosulfan sulfate /does/ not appear to readily leach into the subsoil, little contamination of groundwaters would be expected. No ... endosulfan sulfate residues were detected (method sensitivity 10 ug/l) in well waters located near treated fields in Wisconsin and Florida, 282 and 100 days, respectively, after the last endosulfan application.|Degradation of endosulfan incorporated into sandy loam soil at 6.7 kg/ha ... the sulfate residues were stable for several years.|Endosulfan sulfate ... tended to be more stable ... than either of the two endosulfan isomers ... /and was/ not prone to leaching.|Using a structure estimation method based on molecular connectivity indices(1), the Koc for endosulfan sulfate can be estimated to be 3.2X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that endosulfan sulfate is expected to be immobile in soil.

The Henry's Law constant for endosulfan sulfate is estimated as 1.2X10-11 atm-cu m/mole(SRC) from its vapor pressure, 1.0X10-11 mm Hg(1), and water solubility, 0.48 mg/l(2). This Henry's Law constant indicates that endosulfan sulfate is not expected to volatilize from water surfaces(3). Endosulfan sulfate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.0X10-11 mm Hg(1).

Residues found in the Brantas River system, and Madura Sea, and the canals and ponds in the Brantas River system for endosulfan sulfate collected during March, where a major portion of the spraying was also carried out during this period (ie rainy season, January-April (range) were: Canals <0.01 - 0.55 ug/l; Fish ponds: <0.01-0.44 ug/l; River system 0.1-0.45 ug/l; Madura Sea: <0.01-0.28 ug/l.|No ... endosulfan sulfate residues were detected (method sensitivity 10 ug/l) in well waters located near treated fields in Wisconsin and Florida 282 and 100 days respectively, after the last endosulfan application.|SURFACE WATER: Endosulfan sulfate was not detected in 850 surface water samples contained within the USEPA STORET database(1).|GROUNDWATER: In a study of 1,969 groundwater wells located in the United States, endosulfan sulfate was detected in only 6 at a concn ranging from 0.05-1.4 ug/l(1). Groundwater samples from the Biscayne Aquifer region in Florida contained endosulfan sulfate at a max concn of 0.18 ug/l(2). Organochlorine insecticide were monitored in groundwater from a rural area near Farrukhabad in the vicinity of the Ganga River in northern India from 1991-1992(3). Ten samples taken from ten different locations did not contain any detectable level of endosulfan sulfate(3).|For more Environmental Water Concentrations (Complete) data for ENDOSULFAN SULFATE (6 total), please visit the HSDB record page.

/Endosulfan/ sulfate has been detected in extracts of leafy vegetables, reaching a maximum at 10-12 days after endosulfan application.|Endosulfan sulfate was detected in US Market Basket Surveys, adult total diet samples: Oct 1980-March 1982, 27 composite samples each, potatoes, 33% pos, 2-20 ppb, avg all samples 2.4 ppb; leafy vegetables, 37% pos, 2-185 ppb, avg 17.9 ppb; garden fruits, 33% pos, trace-16 ppb, avg 2 ppb; fruits, 15% pos, 1-3 ppb, avg 0.3 ppb(1); Oct 1979-Sept 1980, 20 composite samples each, potatoes, 5% pos, 4 ppb, avg all samples, 0.2 ppb; leafy vegetables, 20% pos, 2-6 ppb, avg 0.8 ppb; garden fruits, 25% pos, 1-4 ppb, avg 0.5 ppb; fruits, 25% pos, 1-7 ppb, avg 0.8 ppb(2); Oct 1978- Sept 1979, 20 composite samples each, leafy vegetables, 30% pos, 1-27 ppb, avg all samples, 3 ppb; legume vegetables, 5% pos, 3 ppb, avg 0.1 ppb; garden fuits, 10% pos, 1-2 ppb, avg 0.1 ppb; fruits, 15% pos, 1-9 ppb, avg 0.6 ppb(3); Oct 1977-Sept 1978, 240 food composites, 5.8% pos, 2-14 ppb(4); Aug 1976-Sept 1977, 300 food composites, 5.3% pos, 2-20 ppb(5); Aug 1975-July 1976, 240 composites, 5.4% pos, 3-30 ppb(6). Infant (toddler) total diet samples: Oct 1980-March 1982, 130 composites, 3.8% pos, trace-10 ppb (4.6% pos, 2-17 ppb)(7); Oct 1979-Sept 1980, 110 composites, 1.8% pos, 2-3 ppb (1.8% pos, trace-20 ppb)(8); Oct 1978-Sept 1979, 110 composites, 0.9% pos, 4 ppb (not detected)(9); Oct 1977-Sept 1978, 10 composites, 1.8% pos, 1-4 ppb (1.8% pos, 4-5 ppb)(10); Aug 1976-Sept 1977, 117 infant composites, not detected (132 toddler composites, 0.8% pos, 2 ppb)(11).|The FDA collected and analyzed 545 domestic mixed feed rations during fiscal years 1989-1994(1). Endosulfan sulfate(along with endosulfan) was detected in 2 of the 545 samples tested ranging from 0.030-0.140 ppm(1). In a monitoring study of 448 samples of national butter brands collected from the central region of Veracuz, Mexico, endosulfan sulfate was detected at an avg concn of 0.017 mg/kg in fat basis in 10% of the samples(2). The pesticide content of 27,065 food samples from CA, FL, IN, MA, MI, NC, NY, OR, VA and WI were analyzed for pesticides during the fiscal years 1988-89(3). Endosulfan sulfate was detected in fiscal year 1988 in 0.278% of the samples with 3 samples having significantly high levels (concentration exceeded state or federal tolerance level) and in fiscal year 1989 in 0.374% of the samples with only 1 sample having significantly high levels(3).

Endosulfan sulfate ... was present in cows milk ... up to 0.010 mg/l.|Endosulfan sulfate was not detected in a study of 15 human milk samples from the Spanish Mediterranean coastal area and 45 infant formulas samples(1). Six samples of cow milk from various locations in Switzerland were analyzed for chlorinated contaminants(2). Endosulfan sulfate was detected in all six samples ranging from 1.3-4.8 ug/g on fat basis(2). In a monitoring study of 355 samples of cow's milk collected from the central region of Veracuz, Mexico, endosulfan sulfate was not detected(3).

Food is the main source of exposure of the general population to endosulfan. ... Dermal exposure is another /potential route of entry/ in occupationally exposed /individuals/. /Total of alpha and beta endosulfan and endosulfan sulfate/|The general population may be exposed to endosulfan sulfate primarily via ingestion of food(1,2).

ENDOSULFAN WAS APPLIED TO FORAGE CROPS ON WHICH CATTLE WERE ALLOWED TO GRAZE BEGINNING SEVEN DAYS AFTER APPLICATION. ENDOSULFAN SULFATE WAS FOUND IN THE SILAGE & IN THE FAT OF ONLY ONE ANIMAL. ... NO DETECTABLE RESIDUES WERE FOUND IN THE MILK FROM DAIRY COWS FED THE TREATED SILAGE.|The principal route of excretion for endosulfan and endosulfan sulfate is in the feces.

ADMINISTRATION OF THE /ENDOSULFAN/ SULFATE /ORALLY OR IP TO RATS/ ... GAVE RISE TO THE HYDROXYETHER & LACTONE.|IN GREEN /TOBACCO/ LEAVES, ENDOSULFAN SULFATE WAS METABOLIZED INTO ENDOSULFAN I, WHILE DURING CURING THE SULFATE RESIDUE WAS CONVERTED TO ENDOSULFAN II. IT IS ASSUMED THAT THE CONVERSION OF THE SULFATE IN THE INTACT LEAF INTO ENDOSULFAN I IS GOVERNED BY AN ENZYME WHICH IS LOST DURING THE CURING PROCESS.|IN TEMP STRESSED RATS ORALLY DOSED WITH ENDOSULFAN I OR II, ENDOSULFAN SULFATE WAS THE METABOLITE MOST COMMONLY RECOVERED FROM TISSUES, ORGANS & FECES REGARDLESS OF TEMP STRESS. THE DIOL, ALPHA-HYDROXY ETHER & LACTONE ... WERE FOUND IN MOST URINE & FECES SAMPLES.|... WHITE MICE (BALB/C STRAIN) WERE FED (14)C-LABELED ENDOSULFAN. THE TWO ISOMERS WERE NOT COMPLETELY ABSORBED FROM GI TRACT BUT, ALONG WITH ENDOSULFAN SULFATE & DIOL, WERE EXCRETED IN FECES. ONLY A TRACE OF OXIDIZED ENDOSULFAN WAS FOUND IN KIDNEY & MUSCLE EXTRACTS BUT NEITHER OF THE TWO KNOWN METABOLITES NOR ENDOSULFAN WAS FOUND IN BLOOD OR BRAIN EXTRACTS. ... LARGE AMOUNTS OF ENDOSULFAN SULFATE WERE DETECTED IN THE LIVER & TRACES IN THE KIDNEY 24 HR AFTER /MICE/ ... RECEIVED SINGLE DOSES OF ENDOSULFAN.|For more Metabolism/Metabolites (Complete) data for ENDOSULFAN SULFATE (11 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Adininister oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures, reduce all external stimuli, and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... /Aldrin, dieldrin, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam (Valium) ... Use proparacaine hydrochloride to assist eye irrigation ... /Aldrin, dieldrin, and related compounds/

The usual symptoms include headache, giddiness, nervousness, blurred vision, weakness, nausea, cramps, diarrhea, and discomfort in the chest. Signs include sweating, miosis, tearing, salivation and other excessive respiratory tract secretion, vomiting, cyanosis, papilledema, uncontrollable muscle twitches followed by muscular weakness, convulsions, coma, loss of reflexes, and loss of sphincter control. The last four signs are seen only in severe cases but do not preclude a favorable outcome if treatment is prompt and energetic. Cardiac arrhythmias, various degrees of heart block, and cardiac arrest may occur ... /Organic phosphorus pesticides/

endosulfan sulfate

DETERMINATION OF ENDOSULFAN SULFATE IN WATER BY FUSED SILICA CAPILLARY COLUMN GAS CHROMATOGRAPHY/MASS SPECTROMETRY & PACKED COLUMN GAS CHROMATOGRAPHY/MASS SPECTROMETRY WAS STUDIED.|DETERMINATION OF ENDOSULFAN SULFATE IN WATER BY THERMALLY MODULATED ELECTRON CAPTURE DETECTION & 2 DIMENSIONAL GAS CHROMATOGRAPHY WAS STUDIED.|DETERMINATION OF ENDOSULFAN SULFATE IN MUNICIPAL WASTEWATER & SLUDGE BY GAS CHROMATOGRAPHY WAS STUDIED/|AOAC Method 990.06. Organochlorine Pesticides in Finished Drinking Water by Gas Chromatographic Method.|For more Analytic Laboratory Methods (Complete) data for ENDOSULFAN SULFATE (16 total), please visit the HSDB record page.

DETERMINATION OF ENDOSULFAN SULFATE IN ... HUMAN LIVER EXTRACTS BY HIGH-PERFORMANCE LIQUID SEPARATION OF ENDOSULFAN & METABOLITES FROM ANIMAL FAT UTILIZING GAS ENDOSULFAN SULFATE IN FATS BY GEL CHROMATOGRAPHY WAS STUDIED.|THREE STATIONARY PHASES FOR SEPARATION OF ENDOSULFAN & METABOLITES FROM ANIMAL FAT UTILIZING GAS CHROMATOGRAPHY.|A new solvent system, 1% and 2% acetone in hexane, was developed for chromatography on partially inactivated Florisil to facilitate the separation of isomers of endosulfan and its metabolites from fish tissues under tropical conditions. By using the colorimetric method of Maitlen et al., the minimum detectable limit for each isomer of endosulfan in various fish tissues is 5 ng. With this solvent system, the two isomers present in the technical material can be separated, so their toxicity to fish can be assessed separately. /Endosulfan & metabolites/

Environmental transformation -> Pesticide transformation products (metabolite, successor)

Endosulfan sulfate is a known environmental transformation product of endosulfan.|Endosulfan sulfate is a known environmental transformation product of Endosulfan.