Ethambutol dihydrochloride
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Ethambutol dihydrochloride
structure -
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CAS No:
1070-11-7
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Formula:
C10H24N2O2.2ClH
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Chemical Name:
Ethambutol dihydrochloride
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Synonyms:
ETHAMBUTOL HCL USP;Emb, 2,2μ-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride;(R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride;(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediaMine Dihydrochloride;(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride;Ethambutol Hydrochlorid;1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, hydrochloride (1), (2S,2'S)-;Esanbutol
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CAS No:
Description
Ethambutol Dihydrochloride is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.Target: AntibacterialEthambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria
Ethambutol Hydrochloride is the hydrochloride salt form of ethambutol, an ethylenediamine derivative with antibacterial activity, specifically effective against mycobacteria. Although the exact mechanism of action of ethambutol hydrochloride is unknown, ethambutol hydrochloride inhibits the transfer of mycolic acids into the cell wall of bacteria, which impedes bacterial cell growth. This agent may also interfere with RNA synthesis or inhibit other cell metabolism, thereby preventing cell multiplication and causing cell death.|An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
White Powder
ChEBI: The dihydrchloride salt of ethambutol. A bacteriostatic antimycobacterial drug, it is effective against Mycobacterium tuberculosis and some other mycobacteria. It is used in combination with other antituberculous drugs in the treatment of pulm nary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol dihydrochloride is used alone.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Ethambutol dihydrochloride Basic Attributes
277.23
276.137146
213-970-7
QE4VW5FO07
DTXSID4045345
C29033
white
29419000
Characteristics
64.5
2.09320
white
198-200°C
345.3ºC at 760 mmHg
113.7ºC
Slightly soluble in water
Refrigerator
3.35E-07mmHg at 25°C
D25 +7.6° (c = 2 in water)
147 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
2-8°C
Safety Information
IRRITANT
NONH for all modes of transport
3
T,Xi
53-22-36/37/39-45-36/37-26
EL3854000
T,Xi
P201-P308 + P313
61-36/37/38
|Danger|H360 (97.67%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 43 companies from 4 notifications to the ECHA C&L Inventory.
Drug Information
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)
Dexambutol
Ethambutol dihydrochloride Use and Manufacturing
Antibacterial (tuberculostatic)
Antituberculous
Ethambutol dihydrochloride it acts as a tuberculostatic antibacterial agent. It is used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:277.23
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:276.1371335
Monoisotopic Mass:276.1371335
Topological Polar Surface Area:64.5
Heavy Atom Count:16
Complexity:109
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Synthetic antibacterial anti-tuberculosis drug. It has strong activity against bacteria in the growth and reproduction stage, and has almost no effect on bacteria in the dormant stage. It has high antibacterial activity against various types of mycobacteria. There is no cross-resistance between Mycobacterium tuberculosis and other drugs. It may inhibit the metabolism of sensitive bacteria, inhibit RNA synthesis, and interfere with the protein metabolism of Mycobacterium tuberculosis, thereby causing bacterial death. In large doses, it can cause cleft palate, brain exposure, and spinal deformity in mouse experiments; it can cause mild cervical deformity in rat experiments; it can cause cyclops, short limbs, and cleft palate in rabbit experiments.
Registered Holders
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LUPIN LIMITED
Active![Brazil]()
Brazil
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Biobetta Pharmaceuticals (Shanghai) Co., Ltd.
Active![China]()
China
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Minsheng Group Shaoxing Pharmaceutical Co., Ltd.
Active![China]()
China
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