5-BROMO-2-METHYLINDOLE
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5-BROMO-2-METHYLINDOLE
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CAS No:
1075-34-9
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Formula:
C9H8BrN
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Chemical Name:
5-BROMO-2-METHYLINDOLE
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Synonyms:
5-BROMO-2-METHYLINDOLE;2-METHYL-5-BROMOINDOLE;5-BROMO-2-METHYL-1H-INDOLE;1H-Indole,5-bromo-2-methyl-
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CAS No:
Characteristics
15.8
2.7
1.4916 g/cm3
104-107 °C(lit.)
147-148 °C(Press: 4 Torr)
150.4±22.3 °C
1.685
0.000445mmHg at 25°C
Safety Information
NONH for all modes of transport
3
R36/37/38
26-36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-BROMO-2-METHYLINDOLE Use and Manufacturing
Step 1. 5-Bromo-2-methyl-7H-indoleTo a solution of 2-methyl-iH-indole (5.0 g, 38.12 mmol) in sulfuric acid (80 mL) was added AgEXAMPLE 24 2, 2, 2-Trifluoro-1-(5-(3-(isopropyl(methyl)amino)-6-(1H-tetrazol-5-yl)quinoxalin-2-yl)-2-methyl-1H-indol-3-yl)ethanone Step 1. 5-Bromo-2-methyl-1H-indole To a solution of 2-methyl-1H-indole (5.0 g, 38.12 mmol) in sulfuric acid (80 ml) was added AgGeneral procedure: In a 50 ml round bottom flask containing magnetic stir bar was charged with o-nitro benzaldehydes (2 mmol), phosphorane (2.2 mmol), triphenyl phosphine (4.6 mmol) and diphenyl ether (10 mL) and heated at 260