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Clemizole hydrochloride

Clemizole hydrochloride structure

CAS No:
1163-36-6
Formula:
C19H20ClN3.ClH
Chemical Name:
Clemizole hydrochloride
Synonyms:
1H-Benzimidazole,1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-,hydrochloride (1:1);Benzimidazole,1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-,monohydrochloride;1H-Benzimidazole,1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-,monohydrochloride;1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride;1-(4-Chlorobenzyl)-2-(pyrrolidinylmethyl)-1,3-benzimidazole hydrochloride;1-p-Chlorobenzyl-2-pyrrolidylmethyl benzimidazole hydrochloride;Clemizole hydrochloride;Reactrol;Allercur;Klemidox;Histacuran;AL 20;1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole hydrochloride
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.

Clemizole hydrochloride Basic Attributes

Molecular Weight：

362.296

Exact Mass：

361.111267

EC Number：

214-605-4

Characteristics

PSA：

21.06000

XLogP3：

5.07370

Density：

1.25 g/cm3

Melting Point：

239-241 °C

Boiling Point：

506.1ºC at 760 mmHg

Flash Point：

259.9ºC

Water Solubility：

49.5 [ug/mL]

Vapor Pressure：

2.29E-10mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22

safety instructions：

S36

RTECS Number：

DD6730000

Marks：

Xn:Harmful;

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

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Clemizole hydrochloride

CAS No.: 1163-36-6

Content: 99.00%

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