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Dexamethasone acetate

Dexamethasone acetate structure

CAS No:
1177-87-3
Formula:
C24H31FO6
Chemical Name:
Dexamethasone acetate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-,(11β,16α)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16α-methyl-,21-acetate;(11β,16α)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;Dex-Cortidelt acetate;16α-Methyl-9α-fluoroprednisolone 21-acetate;Dexamethasone 21-acetate;Fortecortin (crystal suspension);Dexamethasone acetate;Fortecortin;Decadron LA;Dectancyl;Dexa-Cortisyl;Dalalone LA;Decadronal;Dalalone DP;NSC 39471
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Dexamethasone acetate is a glucocorticoid receptor agonist.

Dexamethasone acetate is a corticosteroid hormone.|Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions. Developed in 1957, dexamethasone is structurally similar to other corticosteroids such as [hydrocortisone] and [prednisolone]. Dexamethasone acetate has largely been replaced by [dexamethasone] phosphate and continues to be administered for a large variety of inflammatory conditions. Recently, dexamethasone has been a drug of interest in the treatment of COVID-19. In a June 16 2020 press release highlighting early results of a clinical trial, Randomized Evaluation of COVID-19 Therapy (RECOVERY), it was reported that dexamethasone reduced COVID-19 deaths by approximately one-fifth and one-third in patients on oxygen therapy and mechanical ventilation, respectively. Dexamethasone was therefore recommended as a life-saving treatment for COVID-19 patients experiencing severe respiratory symptoms.

Dexamethasone acetate Basic Attributes

Molecular Weight：

434.49800

Exact Mass：

434.50

EC Number：

214-646-8

UNII：

K7V8P532WP

NSC Number：

39471

DSSTox ID：

DTXSID8022901

HScode：

2937229000

Characteristics

PSA：

100.90000

XLogP3：

2.46650

Appearance：

White or almost white crystalline powder

Density：

1.3 g/cm3

Melting Point：

263 °C

Boiling Point：

579.4ºC at 760 mmHg

Flash Point：

304.2ºC

Refractive Index：

87 ° (C=1, Dioxane)

Water Solubility：

1.26e-05 M

Storage Conditions：

2-8ºC

Vapor Pressure：

7.75E-16mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R43

safety instructions：

S36/37

RTECS Number：

TU4050000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H317

GHS Classification：

|Danger|H317 (47.78%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P272, P280, P281, P302+P352, P308+P313, P314, P321, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 90 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Transformations：

Dexamethason-21-acetate is a known transformation product of Dexamethasone.

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

MeSH Entry Terms：

dexamethasone acetate

Dexamethasone acetate Use and Manufacturing

Uses

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

Manufacturing Info：

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-: ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals|Pharmaceuticals -> Transformation products

Computed Properties

Molecular Weight:434.5
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:434.21046687
Monoisotopic Mass:434.21046687
Topological Polar Surface Area:101
Heavy Atom Count:31
Complexity:910
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Glucocorticoids, which have anti-inflammatory and anti-allergic effects

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound dexamethasone acetate cream
Ingredients	This product is a compound preparation, containing 0.75 mg of dexamethasone acetate, 10 mg of camphor, and 10 mg of menthol per gram. Excipients are: stearic acid, white vaseline, octadecyl alcohol, glycerin, sodium lauryl sulfate, ethyl hydroxybenzoate, dimethyl sulfoxide, and purified water.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	20 g: 15 mg; 10 g: 7.5 mg

Compound dexamethasone acetate cream
Ingredients	This product is a compound preparation, containing 0.75 mg of dexamethasone acetate, 10 mg of camphor, and 10 mg of menthol per gram. The auxiliary materials are octadecyl alcohol, liquid paraffin, sodium lauryl sulfate, glycerin, paraben, dimethyl sulfoxide, and purified water.
Indication	If you are using other medicines, you should consult your physician or pharmacist before using this product.
Specifications	Compound
Manufacturer	Three Pharmaceutical Drug Group (Wuhu) Co., Ltd.

Compound dexamethasone acetate cream
Ingredients	This product is a compound preparation, containing 0.75 mg of dexamethasone acetate, 10 mg of camphor, and 10 mg of menthol per gram. The auxiliary materials are octadecyl alcohol, liquid paraffin, sodium lauryl sulfate, glycerin, paraben, dimethyl sulfoxide, and purified water.
Indication	If you are using other medicines, you should consult your physician or pharmacist before using this product.
Specifications	Compound
Manufacturer	Jiangsu Yuanheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Tianjin Jinjin Pharmaceutical Co., Ltd.

China
Active
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd.

China
Active
Jinyao Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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