N,N-Dipropylacetamide

Main ingredient: Provaleramide. Chemical name: 2-propylvaleramide. Molecular formula: C8H17NO Molecular weight: 143.23

1. Drinking alcohol can increase the sedative effect. 2. When general anesthetics or central nervous system depressants are used in combination with valproic acid, the pharmacological effect of the former can be more obvious. 3. When used in combination with anticoagulants such as warfarin or heparin, as well as thrombolytics, the risk of bleeding increases. 4. When used in combination with aspirin or dipyridamole, the bleeding time can be prolonged due to reduced platelet aggregation. 5. When used in combination with barbiturates, the metabolism of the latter slows down, and the blood drug concentration increases, thereby increasing the sedative effect and causing drowsiness. 6. When used in combination with primidone, it can also cause an increase in blood drug concentration and lead to poisoning. If necessary, the dosage of primidone needs to be reduced. 7. When used in combination with clonazepam to prevent absence seizures, there have been reports of a few cases where absence seizures were induced. 8. When used in combination with phenytoin sodium, there have been reports of cases where asterixis was caused. Competition with protein binding can change the blood concentration of both drugs. Since the concentration of phenytoin varies greatly, it needs to be measured frequently. However, whether the dosage needs to be adjusted depends on the clinical situation and blood concentration. 9. When used in combination with carbamazepine, the blood concentration and half-life of both drugs can be reduced due to the induction of liver enzymes, so the blood concentration must be monitored to determine whether the dosage needs to be adjusted. 10. When used in combination with drugs that are toxic to the liver, there is a potential risk of liver poisoning. 11. When used in combination with haloperidol, loxapine, maprotiline, monoamine oxidase inhibitors, phenothiazines, thioxanthenes and tricyclic antidepressants, it can increase the inhibition of the central nervous system, reduce the convulsion threshold and the effect of valproic acid, and the dosage must be adjusted in time to control seizures.