18α-Glycyrrhetinic acid
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18α-Glycyrrhetinic acid
structure -
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CAS No:
1449-05-4
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Formula:
C30H46O4
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Chemical Name:
18α-Glycyrrhetinic acid
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Synonyms:
Olean-12-en-29-oic acid,3-hydroxy-11-oxo-,(3β,18α,20β)-;18α-Olean-12-en-30-oic acid,3β-hydroxy-11-oxo-;(3β,18α,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic acid;18α-Glycyrrhetic acid;18α-Glycyrrhetinic acid;18-Isoglycyrrhetinic acid;β-Glycyrrhetinic acid;STX 353;NSC 35350
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CAS No:
Description
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
18α-Glycyrrhetinic acid Basic Attributes
470.68
470.68
215-907-9
35350|35347
DTXSID9020669|DTXSID20872408
2915900090
Characteristics
74.60000
6.57
1.1±0.1 g/cm3
296 °C
588.3±50.0 °C at 760 mmHg
323.7±26.6 °C
1.563
2.71E-16mmHg at 25°C
Safety Information
3
22
ection
RK0190000
Xn
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
12, Po
18α-Glycyrrhetinic acid Use and Manufacturing
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-: ACTIVE
Cosmetics -> Skin conditioning
Computed Properties
Molecular Weight:470.7
XLogP3:6.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:470.33960994
Monoisotopic Mass:470.33960994
Topological Polar Surface Area:74.6
Heavy Atom Count:34
Complexity:965
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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