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Mizolastine

Mizolastine structure

CAS No:
108612-45-9
Formula:
C24H25FN6O
Chemical Name:
Mizolastine
Synonyms:
4(3H)-Pyrimidinone,2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-;4(1H)-Pyrimidinone,2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-;2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone;Mizolastine;MKC 431;SL 850324;Zolistan;Mistamine;Mizollen;2-[[1-[1-[(4-Fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

White SolidMizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzim

Mizolastine is a member of benzimidazoles.|Mizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).

Mizolastine Basic Attributes

Molecular Weight：

432.49

Exact Mass：

432.49

EC Number：

1308068-626-2

UNII：

244O1F90NA

DSSTox ID：

DTXSID5046801

ATC Code：

R06AX25|R - Respiratory system

HScode：

2933990090

Characteristics

PSA：

65.8

XLogP3：

3.42

Density：

1.34±0.1 g/cm3(Predicted)

Melting Point：

217°

Refractive Index：

1.682

Safety Information

RTECS Number：

UW7481284

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)

MeSH Entry Terms：

Mistalin

Mizolastine Use and Manufacturing

Allergic rhinitis;Blocking H1 receptors

Computed Properties

Molecular Weight:432.5
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:432.20738760
Monoisotopic Mass:432.20738760
Topological Polar Surface Area:65.8
Heavy Atom Count:32
Complexity:728
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

2-[[[1-[(4-Fluorophenyl)methyl]-1H-benzoimidazol-2-yl]-4-piperidinyl]methyl-amino]-4(3H)-pyrimidinone

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Mizolastine extended-release tablets
Ingredients	Mizolastine. Chemical name: 2-[[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methyl-amino]-4(3H)-pyrimidinone
Indication	Caution should be exercised when used in combination with drugs that inhibit liver oxidation, such as cimetidine, cyclosporine, and nifedipine. The plasma concentration of this product can be moderately increased when used in combination with macrolide antibiotics or systemic imidazole antifungal drugs.
Specifications	10 mg x 7 tablets

Mizolastine

Mizolastine
Manufacturer	Beijing Jialin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Opella Healthcare Shanghai Ltd

China
Active
Shenyang Sanjiu Pharmaceutical Co., Ltd.

China
Active
Beijing Jialin Pharmaceutical Co., Ltd.

China
Active

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Recommended Suppliers of Mizolastine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Mizolastine

CAS No.: 108612-45-9

Content: 99.00%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Mizolastine108612-45-9

CAS No.: 108612-45-9

Grade: Pharmaceutical Grade

Content: 99%

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